Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling.
Emerging Roles of Estrogen-Related Receptors in the Brain: Potential Interactions with Estrogen Signaling.
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DOI：
10.3390/ijms19041091
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发表时间：
2018-04-05
影响因子：
5.6
通讯作者：
Cui H
中科院分区：
文献类型：
--
作者：
Saito K;Cui H
除了在女性生殖系统中的众所周知的作用外，雌激素还可以在大脑中起作用，以调节两性的广泛行为和生理功能。在过去的几十年里，转基因动物模型极大地增加了我们对脑中雌激素受体（ER）信号传导在行为和生理调节中的作用的认识。然而，雌激素相关受体（ERRs），孤儿核受体的成员，其序列与ER同源，但缺乏雌激素结合能力的关注较少。虽然雌激素受体的内源性配体仍有待确定，它们似乎与雌激素受体共享转录靶点，并且它们的表达可以通过嵌入在雌激素受体编码基因的调控区内的雌激素反应元件直接受雌激素受体调控。尽管ERRs在大脑中广泛表达，但我们才刚刚开始了解它们在分子，细胞和电路水平上发挥的基本作用。在这里，我们回顾了最近的研究进展，了解在大脑中的ERs和ERRs的作用，特别强调ERRs，并讨论可能的串扰之间的ERs和ERRs的行为和生理调节。
In addition to their well-known role in the female reproductive system, estrogens can act in the brain to regulate a wide range of behaviors and physiological functions in both sexes. Over the past few decades, genetically modified animal models have greatly increased our knowledge about the roles of estrogen receptor (ER) signaling in the brain in behavioral and physiological regulations. However, less attention has been paid to the estrogen-related receptors (ERRs), the members of orphan nuclear receptors whose sequences are homologous to ERs but lack estrogen-binding ability. While endogenous ligands of ERRs remain to be determined, they seemingly share transcriptional targets with ERs and their expression can be directly regulated by ERs through the estrogen-response element embedded within the regulatory region of the genes encoding ERRs. Despite the broad expression of ERRs in the brain, we have just begun to understand the fundamental roles they play at molecular, cellular, and circuit levels. Here, we review recent research advancement in understanding the roles of ERs and ERRs in the brain, with particular emphasis on ERRs, and discuss possible cross-talk between ERs and ERRs in behavioral and physiological regulations.
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影响因子：
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作者：
Gantner, Marin L.;Hazen, Bethany C.;Kralli, Anastasia
通讯作者：
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通讯作者：
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影响因子：
16.2
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