Sodium entry during action potentials of mammalian neurons: incomplete inactivation and reduced metabolic efficiency in fast-spiking neurons.
Sodium entry during action potentials of mammalian neurons: incomplete inactivation and reduced metabolic efficiency in fast-spiking neurons.
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哺乳动物神经元动作电位期间的钠进入：快速刺激神经元的灭活不完全失活和代谢效率降低。
DOI：
10.1016/j.neuron.2009.12.011
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发表时间：
2009-12-24
期刊：
影响因子：
16.2
通讯作者：
Bean, Bruce P.
中科院分区：
文献类型：
--
作者：
Carter, Brett C.;Bean, Bruce P.
我们测量了37℃下小鼠中枢神经元动作电位中钠离子进入的时间过程，以研究钠离子进入与去极化耦合的效率。在皮质锥体神经元中，钠离子的进入几乎完全局限于峰值的上升阶段：仅比峰值去极化所需的理论最小值多~25%。然而，在快速尖峰的gaba能神经元（小脑浦肯野细胞和皮质中间神经元）中，进入的钠量是理论最小值的两倍。额外的进入发生是因为钠离子通道失活在尖峰下降阶段是不完全的。钠离子进入不同细胞类型的效率主要是动作电位形状的函数，而不是钠离子通道动力学的细胞类型特异性差异。快速尖峰gaba能神经元的窄尖峰导致钠通道不完全失活；这降低了代谢效率，但可能增强了高频放电的能力。
We measured the time course of sodium entry during action potentials of mouse central neurons at 37 °C to examine how efficiently sodium entry is coupled to depolarization. In cortical pyramidal neurons, sodium entry was nearly completely confined to the rising phase of the spike: only ~25% more sodium enters than the theoretical minimum necessary for spike depolarization. However, in fast-spiking GABAergic neurons (cerebellar Purkinje cells and cortical interneurons), twice as much sodium enters as the theoretical minimum. The extra entry occurs because sodium channel inactivation is incomplete during the falling phase of the spike. The efficiency of sodium entry in different cell types is primarily a function of action potential shape and not cell type-specific differences in sodium channel kinetics. The narrow spikes of fast-spiking GABAergic neurons result in incomplete inactivation of sodium channels; this reduces metabolic efficiency but likely enhances the ability to fire spikes at high frequency.
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