Physiological imaging-defined, response-driven subvolumes of a tumor.
Physiological imaging-defined, response-driven subvolumes of a tumor.
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DOI：
10.1016/j.ijrobp.2012.10.036
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发表时间：
2013-04-01
影响因子：
7
通讯作者：
Cao, Yue
中科院分区：
文献类型：
--
作者：
Farjam, Reza;Tsien, Christina I.;Feng, Felix Y.;Gomez-Hassan, Diana;Hayman, James A.;Lawrence, Theodore S.;Cao, Yue
Dose painting of the physiological imaging-defined subvolumes of the tumors by intensity-modulated radiotherapy is hypothesized to lead to a better outcome than distributing a uniform dose within a target volume defined by anatomic imaging. We developed a general method to delineate the subvolumes of a tumor based upon multiple physiological imaging and tested their complementary roles for assessment of therapy response. To develop an image analysis framework to delineate the physiological imaging-defined subvolumes of a tumor in relating to treatment response and outcome. Our proposed approach delineates the subvolumes of a tumor based upon its heterogeneous distributions of physiological imaging parameters. The method assigns each voxel a probabilistic membership function belonging to the physiological parameter classes defined in a sample of tumors, and then calculates the related subvolumes in each tumor. We applied our approach to regional cerebral blood volume (rCBV) and Gd-DTPA transfer constant (Ktrans) images of patients who had brain metastases and were treated by whole brain radiotherapy (WBRT). Forty-five lesions were included in the analysis. Changes in the rCBV (or Ktrans)-defined subvolumes of the tumors from pre RT to 2 weeks (2W) after the start of WBRT were evaluated for differentiation of responsive, stable and progressive tumors using Mann-Whitney U test. Performance of the newly developed metrics for predicting tumor response to WBRT was evaluated by Receiver Operating Characteristic (ROC) analysis. The percentage decrease in the high-CBV defined subvolumes of the tumors from pre-RT to 2W was significantly greater in the group of responsive tumors than the group of stable and progressive ones (p<0.007). The change in the high-CBV defined subvolumes of the tumors from pre-RT to 2W was a predictor for post-RT response significantly better than change in the gross tumor volume observed during the same time interval (p=0.012), suggesting the physiological change occurs prior to the volumetric change. Also, Ktrans did not add significant discriminatory information for assessing response with respect to rCBV. The physiological imaging-defined subvolumes of the tumors delineated by our method could be a candidate for boost target, for which further development and evaluation is warranted.
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影响因子：
82.9
作者：
通讯作者：
--
影响因子：
--
作者：
DELATTRE, JY;KROL, G;POSNER, JB
通讯作者：
POSNER, JB
DOI：
10.1016/s0360-3016(00)01511-x
发表时间：
2001-04-01
影响因子：
7
作者：
Huber, PE;Hawighorst, H;Debus, J
通讯作者：
Debus, J
影响因子：
5.7
作者：
Menegakis, Apostolos;Eicheler, Wolfgang;Baumann, Michael
通讯作者：
Baumann, Michael
DOI：
10.1016/j.ijrobp.2005.09.001
发表时间：
2006-03-01
影响因子：
7
作者：
Cao, Y;Tsien, CI;Lawrence, TS
通讯作者：
Lawrence, TS