Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.
复制标题
靶向疾病中的氧化应激：抗氧化治疗的前景和局限性。
DOI：
10.1038/s41573-021-00233-1
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Forman HJ;Zhang H
氧化应激是许多疾病的组成部分，包括动脉粥样硬化、慢性阻塞性肺病、阿尔茨海默病和癌症。尽管许多被评估为抗氧化剂的小分子在临床前研究中表现出治疗潜力，但临床试验结果令人失望。更好地了解抗氧化剂的作用机制以及它们在何时何地有效可能会提供一种合理的方法，从而获得更大的药理学成功。在这里，我们回顾氧化应激，氧化还原信号和疾病之间的关系，通过氧化应激可以有助于病理机制，抗氧化防御如何工作，是什么限制了它们的有效性，以及如何通过生理信号，饮食成分和潜在的药物干预，可以增加抗氧化防御。虽然氧化应激与广泛的疾病有关，但抗氧化剂治疗方法迄今为止令人失望。在这里，Forman和Zhang回顾了氧化应激和氧化还原信号在疾病中的作用，评估了抗氧化剂治疗策略，并强调了挑战其临床应用的关键限制。
Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, clinical trial results have been disappointing. A greater understanding of the mechanisms through which antioxidants act and where and when they are effective may provide a rational approach that leads to greater pharmacological success. Here, we review the relationships between oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can contribute to pathology, how antioxidant defences work, what limits their effectiveness and how antioxidant defences can be increased through physiological signalling, dietary components and potential pharmaceutical intervention. Although oxidative stress is associated with a broad range of diseases, therapeutic antioxidant approaches have so far been disappointing. Here, Forman and Zhang review the roles of oxidative stress and redox signalling in disease, assess antioxidant therapeutic strategies and highlight key limitations that have challenged their clinical application.
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DOI：
10.1016/j.ijrobp.2017.10.019
发表时间：
2018-02-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Anderson CM;Sonis ST;Lee CM;Adkins D;Allen BG;Sun W;Agarwala SS;Venigalla ML;Chen Y;Zhen W;Mould DR;Holmlund JT;Brill JM;Buatti JM
通讯作者：
Buatti JM
影响因子：
24
作者：
Blum, Shany;Asaf, Roy;Levy, Andrew P.
通讯作者：
Levy, Andrew P.
影响因子：
7.4
作者：
Batinic-Haberle, I;Spasojevic, I;Fridovich, I
通讯作者：
Fridovich, I
影响因子：
7.4
作者：
Bruno, RS;Leonard, SW;Traber, MG
通讯作者：
Traber, MG
影响因子：
15.9
作者：
BABIOR, BM;KIPNES, RS;CURNUTTE, JT
通讯作者：
CURNUTTE, JT