A mechanochemical model of cell reorientation on substrates under cyclic stretch.
A mechanochemical model of cell reorientation on substrates under cyclic stretch.
复制标题
循环拉伸下基底上细胞重新定向的机械化学模型
DOI：
10.1371/journal.pone.0065864
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gao H
中科院分区：
文献类型：
--
作者：
Qian J;Liu H;Lin Y;Chen W;Gao H
We report a theoretical study on the cyclic stretch-induced reorientation of spindle-shaped cells. Specifically, by taking into account the evolution of sub-cellular structures like the contractile stress fibers and adhesive receptor-ligand clusters, we develop a mechanochemical model to describe the dynamics of cell realignment in response to cyclically stretched substrates. Our main hypothesis is that cells tend to orient in the direction where the formation of stress fibers is energetically most favorable. We show that, when subjected to cyclic stretch, the final alignment of cells reflects the competition between the elevated force within stress fibers that accelerates their disassembly and the disruption of cell-substrate adhesion as well, and an effectively increased substrate rigidity that promotes more stable focal adhesions. Our model predictions are consistent with various observations like the substrate rigidity dependent formation of stable adhesions and the stretching frequency, as well as stretching amplitude, dependence of cell realignment. This theory also provides a simple explanation on the regulation of protein Rho in the formation of stretch-induced stress fibers in cells.
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影响因子：
2.9
作者：
Arnold, M;Cavalcanti-Adam, EA;Spatz, JP
通讯作者：
Spatz, JP
影响因子：
41.2
作者：
Deng, Linhong;Trepat, Xavier;Fredberg, Jeffrey J.
通讯作者：
Fredberg, Jeffrey J.
影响因子：
19.6
作者：
De, Rumi;Zemel, Assaf;Safran, Samuel A.
通讯作者：
Safran, Samuel A.
DOI：
10.1098/rspb.1938.0050
发表时间：
1938-10-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Hill, AV
通讯作者：
Hill, AV
影响因子：
21.3
作者：
Balaban, NQ;Schwarz, US;Geiger, B
通讯作者：
Geiger, B