Metformin as a Tool to Target Aging.

Metformin as a Tool to Target Aging.
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DOI:
10.1016/j.cmet.2016.05.011
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发表时间:
2016-06-14
期刊:
影响因子:
29
通讯作者:
Espeland MA
Espeland MA
中科院分区:
生物学1区
文献类型:
--
作者:
Barzilai N;Crandall JP;Kritchevsky SB;Espeland MA

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在许多模型中,衰老一直是通过遗传和饮食操作以及药物来延长寿命和健康寿命的目标。二甲双胍已经显示出对人类几种与年龄有关的疾病的保护作用,它将在TAME(用二甲双胍靶向衰老)试验中进行测试,作为开发日益有效的下一代药物的第一步。
Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
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