Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated Complications.
Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated Complications.
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DOI：
10.3390/ijms241814015
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发表时间：
2023-09-13
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
鞘脂在1型和2型糖尿病的发展中以及在微血管和大血管并发症的发展中发挥重要作用。关于神经鞘脂在糖尿病中的作用已经发表了一些综述，但大多数的重点是神经鞘脂，主要是神经酰胺，促进糖尿病发展的可能机制。关于血清和脂蛋白中不同类型鞘脂的循环水平及其作为预测糖尿病发展及其并发症的生物标志物的重要性的研究直到最近才出现，而且仍处于起步阶段。本文综述了关于鞘脂介导的糖尿病及其并发症发生机制的文献，重点介绍了循环血浆鞘脂水平和不同脂蛋白携带的相对含量如何影响它们作为可能的生物标志物在糖尿病的发生和糖尿病并发症的发生中的作用。该领域的进一步研究可能会开辟新的治疗途径，以预防或阻止/减少糖尿病的发展及其并发症的进展。
Sphingolipids play an important role in the development of diabetes, both type 1 and type 2 diabetes, as well as in the development of both micro- and macro-vascular complications. Several reviews have been published concerning the role of sphingolipids in diabetes but most of the emphasis has been on the possible mechanisms by which sphingolipids, mainly ceramides, contribute to the development of diabetes. Research on circulating levels of the different classes of sphingolipids in serum and in lipoproteins and their importance as biomarkers to predict not only the development of diabetes but also of its complications has only recently emerged and it is still in its infancy. This review summarizes the previously published literature concerning sphingolipid-mediated mechanisms involved in the development of diabetes and its complications, focusing on how circulating plasma sphingolipid levels and the relative content carried by the different lipoproteins may impact their role as possible biomarkers both in the development of diabetes and mainly in the development of diabetic complications. Further studies in this field may open new therapeutic avenues to prevent or arrest/reduce both the development of diabetes and progression of its complications.
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影响因子：
7.7
作者：
Buschard, K;Hoy, M;Gromada, J
通讯作者：
Gromada, J
影响因子：
15.9
作者：
Anderson, Ethan J.;Lustig, Mary E.;Neufer, P. Darrell
通讯作者：
Neufer, P. Darrell
影响因子：
--
作者：
Bleich, D;Polak, M;Lévy-Marchal, C
通讯作者：
Lévy-Marchal, C
影响因子：
1.9
作者：
BRECKENRIDGE, WC;HALLORAN, JL;SILVER, MD
通讯作者：
SILVER, MD
影响因子：
3.5
作者：
Arianti, Rini;Vinnai, Boglarka Agnes;Fesus, Laszlo
通讯作者：
Fesus, Laszlo