Translating metabolic exchange with imaging mass spectrometry.
Translating metabolic exchange with imaging mass spectrometry.
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DOI:
10.1038/nchembio.252
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发表时间:
2009-12
影响因子:
14.8
通讯作者:
Dorrestein PC
中科院分区:
文献类型:
--
作者:
Yang YL;Xu Y;Straight P;Dorrestein PC
Metabolic exchange between an organism and the environment, including interactions with neighboring organisms, is important for processes of organismal development. Here we develop and use thin-layer agar natural product MALDI-TOF imaging mass spectrometry of intact bacterial colonies grown on top of the MALDI target plate to study an interaction between two species of bacteria and provide direct evidence that a Bacillus subtilis silences the defensive arsenal of Streptomyces coelicolor.
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