CITED2 is a conserved regulator of the uterine-placental interface.
CITED2 is a conserved regulator of the uterine-placental interface.
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CITED 2是子宫-胎盘界面的保守调节因子。
DOI：
10.1073/pnas.2213622120
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发表时间：
2023-01-17
影响因子：
11.1
通讯作者：
Soares, Michael J.
中科院分区：
文献类型：
--
作者：
Kuna, Marija;Dhakal, Pramod;Iqbal, Khursheed;Dominguez, Esteban M.;Kent, Lindsey N.;Muto, Masanaga;Moreno-Irusta, Ayelen;Kozai, Keisuke;Varberg, Kaela M.;Okae, Hiroaki;Arima, Takahiro;Sucov, Henry M.;Soares, Michael J.
建立子宫-胎盘界面的过程是一个鲜为人知的组织重组事件，涉及遗传上外来的滋养细胞破坏免疫安全的子宫。在最佳情况下，母亲和胎儿会茁壮成长，而失败则是危及生命的妊娠疾病的根本原因。CBP/p300与谷氨酸/天冬氨酸富含羧基末端结构域2(CITED2)相互作用的反式激活因子是一种转录共调节因子，在子宫实质滋养层细胞系中广泛存在。CITED2有助于协调大鼠和人类滋养细胞分化为能够转化子宫的侵袭性/绒毛外滋养细胞。这些行为确保必要的胎盘发育和对生理应激源的适应。CITED2是建立子宫-胎盘界面所必需的转录事件的保守调节因子。绒毛膜子宫-胎盘界面的建立需要滋养细胞从胎盘外流及其对子宫的转化作用，这是对成功妊娠至关重要的过程，但人们对此知之甚少。我们研究了CBP/p300相互作用的反式激活因子与谷氨酸/天冬氨酸富含羧基末端结构域2(CITED2)在大鼠和人滋养层细胞发育中的作用。大鼠和人的胎盘都有很深的血绒膜胎盘。CITED2在大鼠交界区(JZ)和侵袭性滋养层细胞中有明显表达。Cited2基因纯合缺失导致胎盘和胎儿生长受限。小Cited2缺失胎盘的特征是JZ断裂，宫内滋养层细胞侵袭延迟，以及可塑性受损。在人类胎盘部位，CITED2在绒毛外滋养细胞(EVT)细胞柱中唯一表达，并对EVT细胞谱系的发育起重要作用。我们的结论是，CITED2是深血膜胎盘的保守调节因子。
The process of establishing the uterine–placental interface is a poorly understood tissue reengineering event that involves genetically foreign trophoblast cells breaching the immunologically secure uterus. When optimal, mother and fetus thrive, whereas failures represent the root cause of life-threatening diseases of pregnancy. CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) is a transcriptional coregulator with a conspicuous presence in trophoblast cell lineages infiltrating the uterine parenchyma. CITED2 helps coordinate the differentiation of rat and human trophoblast cells into invasive/extravillous trophoblast cells capable of transforming the uterus. These actions ensure requisite placental development and adaptations to physiological stressors. CITED2 exemplifies a conserved regulator of transcriptional events essential for establishing the uterine–placental interface. Establishment of the hemochorial uterine–placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understood. We examined the involvement of CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) in rat and human trophoblast cell development. The rat and human exhibit deep hemochorial placentation. CITED2 was distinctively expressed in the junctional zone (JZ) and invasive trophoblast cells of the rat. Homozygous Cited2 gene deletion resulted in placental and fetal growth restriction. Small Cited2 null placentas were characterized by disruptions in the JZ, delays in intrauterine trophoblast cell invasion, and compromised plasticity. In the human placentation site, CITED2 was uniquely expressed in the extravillous trophoblast (EVT) cell column and importantly contributed to the development of the EVT cell lineage. We conclude that CITED2 is a conserved regulator of deep hemochorial placentation.
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影响因子：
2.9
作者：
Barak Y;Sadovsky Y;Shalom-Barak T
通讯作者：
Shalom-Barak T
DOI：
10.1073/pnas.1708341114
发表时间：
2017-11-07
影响因子：
11.1
作者：
Krendl C;Shaposhnikov D;Rishko V;Ori C;Ziegenhain C;Sass S;Simon L;Müller NS;Straub T;Brooks KE;Chavez SL;Enard W;Theis FJ;Drukker M
通讯作者：
Drukker M
影响因子：
1.5
作者：
Lee, Dong-Soo;Rumi, M. A. Karim;Konno, Toshihiro;Soares, Michael J.
通讯作者：
Soares, Michael J.
影响因子：
9.8
作者：
Brosens, Ivo;Puttemans, Patrick;Benagiano, Giuseppe
通讯作者：
Benagiano, Giuseppe
影响因子：
30.8
作者：
Bamforth, SD;Bragança, J;Bhattacharya, S
通讯作者：
Bhattacharya, S