Cortical hemodynamics as a function of handgrip strength and cognitive performance: a cross-sectional fNIRS study in younger adults.
Cortical hemodynamics as a function of handgrip strength and cognitive performance: a cross-sectional fNIRS study in younger adults.
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DOI：
10.1186/s12868-021-00615-6
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发表时间：
2021-02-15
期刊：
影响因子：
2.4
通讯作者：
Schega L
中科院分区：
文献类型：
--
作者：
Herold F;Behrendt T;Törpel A;Hamacher D;Müller NG;Schega L
越来越多的证据表明，肌肉力量和认知能力之间存在正相关关系。然而，这种关系的神经生理学相关性还没有得到很好的理解。本研究的目的是研究皮质血流动力学[即，氧合血红蛋白（oxyHb）和脱氧血红蛋白（deoxyHb）浓度的变化]作为肌肉力量和认知能力测量之间的可能联系。在一组年轻人（n = 39，18-30岁）中，我们评估了（i）通过手持测力计的握力，（ii）通过使用斯滕贝格任务中的错误率和反应时间的短期工作记忆表现，以及（iii）通过功能性近红外光谱（fNIRS）的前额叶皮质（PFC）的皮质血流动力学。我们观察到低到中度的负相关性，（rp = ~-0.38 to-0.51; p < 0.05）反应时间和PFC特定部位的oxyHb水平之间的相关性。（rp = ~ 0.34至0.45; p < 0.05）。此外，较高水平的oxyHb（rp（35）= 0.401; p = 0.014）和PFC特定部分中较低水平的脱氧血红蛋白（rp（34）=-0.338; p = 0.043）与较高的正确率有关。我们还发现，（p < 0.05）握力测量值与氧合血红蛋白水平之间（rp = ~ 0.35; p < 0.05）和脱氧血红蛋白水平（rp = ~ − 0.25至− 0.49; p < 0.05）。然而，认知能力与握力之间无相关性，前额叶皮层血流动力学也不介导握力与认知能力之间的关系（p > 0.05）。本研究提供了证据，皮质血流动力学和认知性能之间的积极的神经行为关系。我们的研究结果进一步表明，在年轻的成年人更高水平的握力积极影响皮质血流动力学，虽然后者并不一定最终在更好的认知性能。未来的研究应该检查目前的研究结果是否可以推广到其他队列（例如，老年人）。
There is growing evidence for a positive correlation between measures of muscular strength and cognitive abilities. However, the neurophysiological correlates of this relationship are not well understood so far. The aim of this study was to investigate cortical hemodynamics [i.e., changes in concentrations of oxygenated (oxyHb) and deoxygenated hemoglobin (deoxyHb)] as a possible link between measures of muscular strength and cognitive performance. In a cohort of younger adults (n = 39, 18–30 years), we assessed (i) handgrip strength by a handhold dynamometer, (ii) short-term working memory performance by using error rates and reaction times in the Sternberg task, and (iii) cortical hemodynamics of the prefrontal cortex (PFC) via functional near-infrared spectroscopy (fNIRS). We observed low to moderate negative correlations (rp = ~ − 0.38 to − 0.51; p < 0.05) between reaction time and levels of oxyHb in specific parts of the PFC. Furthermore, we noticed low to moderate positive correlations (rp = ~ 0.34 to 0.45; p < 0.05) between reaction times and levels of deoxyHb in distinct parts of the PFC. Additionally, higher levels of oxyHb (rp (35) = 0.401; p = 0.014) and lower levels of deoxyHb (rp (34) = − 0.338; p = 0.043) in specific parts of the PFC were linked to higher percentage of correct answers. We also found low to moderate correlations (p < 0.05) between measures of handgrip strength and levels of oxyHb (rp = ~ 0.35; p < 0.05) and levels of deoxyHb (rp = ~ − 0.25 to − 0.49; p < 0.05) in specific parts of the PFC. However, there was neither a correlation between cognitive performance and handgrip strength nor did cortical hemodynamics in the PFC mediate the relationship between handgrip strength and cognitive performance (p > 0.05). The present study provides evidence for a positive neurobehavioral relationship between cortical hemodynamics and cognitive performance. Our findings further imply that in younger adults higher levels of handgrip strength positively influence cortical hemodynamics although the latter did not necessarily culminate in better cognitive performance. Future research should examine whether the present findings can be generalized to other cohorts (e.g., older adults).
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影响因子：
3.3
作者：
Broscheid KC;Hamacher D;Lamprecht J;Sailer M;Schega L
通讯作者：
Schega L
影响因子：
2.3
作者：
Altamura, Mario;Elvevag, Brita;Goldberg, Terry E.
通讯作者：
Goldberg, Terry E.
影响因子：
4.7
作者：
Backhaus, J;Junghanns, K;Hohagen, F
通讯作者：
Hohagen, F
影响因子：
14.8
作者：
Bowie, Christopher R.;Harvey, Philip D.
通讯作者：
Harvey, Philip D.
DOI：
10.1093/gerona/glw061
发表时间：
2017-02-01
影响因子：
5.1
作者：
Bierre, Kirstin L.;Lucas, Samuel J. E.;Machado, Liana
通讯作者：
Machado, Liana