Inter-Session Reliability of Functional Near-Infrared Spectroscopy at the Prefrontal Cortex While Walking in Multiple Sclerosis.
Inter-Session Reliability of Functional Near-Infrared Spectroscopy at the Prefrontal Cortex While Walking in Multiple Sclerosis.
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DOI：
10.3390/brainsci10090643
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发表时间：
2020-09-17
期刊：
影响因子：
3.3
通讯作者：
Schega L
中科院分区：
文献类型：
--
作者：
Broscheid KC;Hamacher D;Lamprecht J;Sailer M;Schega L
许多已建立的技术在分析运动中的执行功能方面受到限制，特别是在行走时。功能近红外光谱（fNIRS）填补了这一空白。本研究的目的是调查在患有多发性硬化症（MS）和健康对照（HC）个体中行走时，前额叶皮层fNIRS衍生参数的会话间可靠性（ISR）。20名MS/HC患者在12 m的轨道上来回行走6 min。主要结局为Brodmann区域（BA）9/46/10中氧合/脱氧血红蛋白浓度（HbO/HbR）的平均值、斜率系数（SC）和曲线下面积（A）的绝对和相对可靠性。MS患者BA 10中的SC和HbO A显示出公平的ISR。对于HbR的平均值和A，几乎所有观察到的区域都显示出公平的ISR。总体而言，ISR对HbR的影响优于HbO。一个公平的优秀ISR被发现大部分的BA的前额叶皮层在HC个人。总之，分析的fNIRS衍生参数的ISR是有限的。为了改善ISR，应尽量减少疲劳和走神等混杂因素。在报告ISR时，重点应放在平均值/A而不是SC上。
Many established technologies are limited in analyzing the executive functions in motion, especially while walking. Functional near-infrared spectroscopy (fNIRS) fills this gap. The aim of the study is to investigate the inter-session reliability (ISR) of fNIRS-derived parameters at the prefrontal cortex while walking in people with multiple sclerosis (MS) and healthy control (HC) individuals. Twenty people with MS/HC individuals walked a 12 m track back and forth over 6 min. The primary outcomes were the absolute and relative reliability of the mean, slope coefficient (SC), and area under the curve (A) of the oxy-/deoxyhemoglobin concentrations (HbO/HbR) in the Brodmann areas (BA) 9/46/10. The SC and the A of HbO exhibited a fair ISR in BA10 in people with MS. For the mean and A of the HbR, almost all areas observed revealed a fair ISR. Overall, the ISR was better for HbR than HbO. A fair to excellent ISR was found for most BA of the prefrontal cortex in HC individuals. In total, the ISR of the analyzed fNIRS-derived parameters was limited. To improve the ISR, confounders such as fatigue and mind wandering should be minimized. When reporting the ISR, the focus should be on the mean/A rather than SC.
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