Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein.
Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein.
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DOI：
10.1021/jf2034863
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发表时间：
2012-01-11
影响因子：
6.1
通讯作者：
Burow ME
中科院分区：
文献类型：
--
作者：
Wood CE;Boue SM;Collins-Burow BM;Rhodes LV;Register TC;Cline JM;Dewi FN;Burow ME
Glyceollins are stress-induced compounds in soybeans with bioactive properties distinct from parent soy isoflavones. The goals of this study were to evaluate effects of dietary glyceollin-enriched and standard soy protein isolates and identify candidate target pathways of glyceollins on transcriptional profiles within mammary gland tissue. Thirty female postmenopausal cynomolgus monkeys were randomized to diets containing one of three protein sources for 3 weeks: control casein / lactalbumin (C/L); standard soy protein containing 194 mg/day isoflavones (SOY); and glyceollin-enriched soy protein containing 189 mg/day isoflavones + 134 mg/day glyceollins (GLY). All diets contained a physiologic dose of estradiol (E2) (1 mg/day). All doses are expressed in human equivalents scaled by caloric intake. Relative to the control C/L diet, the GLY diet resulted in greater numbers of differentially regulated genes which showed minimal overlap with those of SOY. Effects of GLY related primarily to pathways involved in lipid and carbohydrate metabolism, including peroxisome proliferator-activated receptor (PPAR)-gamma and AMP-activated protein kinase (AMPK) signaling, adipocytokine expression, triglyceride synthesis, and lipase activity. Notable genes upregulated by the GLY diet included PPAR-gamma, adiponectin, leptin, lipin 1, and lipoprotein lipase. The GLY diet also resulted in lower serum total cholesterol, specifically non-high-density lipoprotein cholesterol, and increased serum triglycerides compared to the C/L diet. No effects of GLY or SOY were seen on serum insulin, adipocytokines, or vascular and bone turnover markers. These preliminary findings suggest that glyceollin-enriched soy protein has divergent effects from standard soy with some specificity for adipocyte activity and nutrient metabolism.
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DOI：
10.1097/00042192-200209000-00004
发表时间：
2002-09-01
影响因子：
2.7
作者：
Lees, CJ;Register, TC;Jerome, CP
通讯作者：
Jerome, CP
影响因子：
5.8
作者：
Burow, ME;Boue, SM;McLachlan, JA
通讯作者：
McLachlan, JA
影响因子：
6.5
作者：
Gudbrandsen, Oddrun Anita;Rost, Therese Halvorsen;Berge, Rolf Kristian
通讯作者：
Berge, Rolf Kristian
影响因子：
3.6
作者：
Kim, Hyo Jung;Cha, Byung-Yoon;Kim, Jong-Sang
通讯作者：
Kim, Jong-Sang
影响因子：
5.8
作者：
Register, TC;Cann, JA;Clarkson, TB
通讯作者：
Clarkson, TB