Characteristics of Expression of Matrix Metalloproteinases (MMP-2 and MMP-9) in Glottic Squamous Cell Carcinoma and Benign Vocal Fold Lesions.
Characteristics of Expression of Matrix Metalloproteinases (MMP-2 and MMP-9) in Glottic Squamous Cell Carcinoma and Benign Vocal Fold Lesions.
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DOI：
10.3342/ceo.2015.8.1.57
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发表时间：
2015-03
影响因子：
3
通讯作者：
Lesauskaite V
中科院分区：
文献类型：
--
作者：
Uloza V;Liutkevicius V;Pangonyte D;Lesauskaite V
本研究旨在探讨基质金属蛋白酶（MMP-2和MMP-9）在声门型鳞状细胞癌（SCC）和声带良性病变（BVFL）中的表达及其与临床病理特征的关系。应用免疫组化SP法检测217例声带息肉、30例复发性呼吸道乳头状瘤、36例喉角化病、112例声门鳞状细胞癌及12例正常声带组织中MMP-2、MMP-9的表达。MMP-2和MMP-9在上皮和间质细胞中的表达以半定量量表分级，范围从0（无表达）到18分（高表达）。MMP-2和MMP-9在声门型SCC中的表达均显著高于BVFL组。MMP-2和MMP-9在中、低分化声门型喉癌中的表达均显著高于高分化声门型喉癌（P<0.001和P=0.01）。间质MMP-2表达与淋巴结转移有关（P=0.030）。声门型喉鳞状细胞癌MMP-2、MMP-9的表达与临床分期、肿瘤T值、吸烟、饮酒、年龄无关。MMP-2基质值为11.2点，确定为区分BVFL和声门型SCC患者组的最佳点（限值）。我们的研究结果表明，MMP-2和MMP-9的表达上调已经在BVFL的发展，下一步的决定性步骤是有关的发生硬化。基质MMP-2的极限值表明MMP-2在声门SCC癌变中的预后重要性。
The aim of this study was to investigate expression profile of matrix metalloproteinases (MMP-2 and MMP-9) in glottic squamous cell carcinoma (SCC) and benign vocal fold lesions (BVFLs) and to correlate it with clinical and pathological features. The immunohistochemical expression of MMP-2 and MMP-9 was investigated in specimens taken from 217 patients group, including vocal fold polyps (n=39), recurrent respiratory papillomatosis (n=30), laryngeal keratosis (n=36), glottic SCC (n=112), and the normal tissue of vocal fold (n=12, control group). The expression of MMP-2 and MMP-9, both in epithelium and stroma cells, was graded on a semiquantitative scale, ranging from 0 (no expression) to 18 points (high expression). Expressions of both, MMP-2 and MMP-9 were significantly higher in the glottic SCC group comparing with BVFL group. Significant higher expression of parenchymal MMP-2 (P<0.001) and stromal MMP-9 (P=0.01) was revealed in the group of moderate/poorly differentiated glottic SCC comparing with well differentiated glottic SCC group. Expression of stroma MMP-2 was found to be correlated with nodal metastasis (P=0.030). Expressions of both, MMP-2 and MMP-9 were not correlated with clinical stage, tumor T value, smoking, alcohol use, age in the glottic SSC patients group. The MMP-2 stroma value of 11.2 points was determined as the optimum point (limiting value) for separating BVFL and glottic SCC patient groups. Our results suggest that expressions of both MMP-2 and MMP-9 are up-regulated already in the development of BVFL, the next determinant step is concerned with occurrence of malignization. Limiting value of stroma MMP-2 demonstrates prognostic importance of MMP-2 in glottic SCC carcinogenesis.
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影响因子：
11.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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