Investigation of the PSF-choice method for reduced lipid contamination in prostate MR spectroscopic imaging.
Investigation of the PSF-choice method for reduced lipid contamination in prostate MR spectroscopic imaging.
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DOI：
10.1002/mrm.24132
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发表时间：
2012-11
影响因子：
3.3
通讯作者：
Mulkern, Robert V.
中科院分区：
文献类型：
--
作者：
Panych, Lawrence P.;Roebuck, Joseph R.;Chen, Nan-kuei;Tang, Yi;Madore, Bruno;Tempany, Clare M.;Mulkern, Robert V.
这项工作的目的是评估之前提出的一种方法，该方法旨在改善MR光谱成像（MRSI）的点扩散函数（PSF），以避免受到邻近体素产生的脂质信号的破坏。可以使用回顾性空间滤波来改变PSF，然而，这要么降低空间分辨率，要么需要以增加成像时间为代价延长k空间中的采集。或者，这里评估的方法，PSF选择，可以修改PSF定位，以减少相邻脂质的污染，使信号响应更接近所需的MRSI体素网格。这样做不会增加扫描时间或降低重要代谢物的SNR。PSF-Choice通过修改RF激励脉冲实现了空间定位的改进。该方法的实施报告的前列腺MRSI，它表明，在13个试点前列腺MRSI扫描，从脂质体素内光谱污染显着减少时，使用PSF选择。还进行了体模研究，结果表明，与采用标准傅立叶相位编码的MRSI相比，采用PSF-Choice的MRSI显著减少了光谱的体素外信号污染。
The purpose of this work was to evaluate a previously proposed approach that aims to improve the point-spread-function (PSF) of MR spectroscopic imaging (MRSI) in order to avoid corruption by lipid signal arising from neighboring voxels. Retrospective spatial filtering can be used to alter the PSF, however, this either reduces spatial resolution or requires extending the acquisition in k-space at the cost of increased imaging time. Alternatively, the method evaluated here, PSF-Choice, can modify the PSF localization to reduce the contamination from adjacent lipids by conforming the signal response more closely to the desired MRSI voxel grid. This is done without increasing scan time or degrading SNR of important metabolites. PSF-Choice achieves improvements in spatial localization through modifications to the RF excitation pulses. An implementation of this method is reported for MRSI of the prostate, where it is demonstrated that, in 13 of 16 pilot prostate MRSI scans, intra-voxel spectral contamination from lipid was significantly reduced when using PSF-Choice. Phantom studies were also performed that demonstrate, compared to MRSI with standard Fourier phase encoding, out-of-voxel signal contamination of spectra was significantly reduced in MRSI with PSF-Choice.
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