Through the looking glass: A review of cranial window technology for optical access to the brain.
Through the looking glass: A review of cranial window technology for optical access to the brain.
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透过镜子:一个审查颅窗技术的光学访问大脑。
DOI:
10.1016/j.jneumeth.2021.109100
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发表时间:
2021-04-15
影响因子:
3
通讯作者:
Chen CC
中科院分区:
文献类型:
--
作者:
Cramer SW;Carter RE;Aronson JD;Kodandaramaiah SB;Ebner TJ;Chen CC
Deciphering neurologic function is a daunting task, requiring understanding the neuronal networks and emergent properties that arise from the interactions among single neurons. Mechanistic insights into neuronal networks require tools that simultaneously assess both single neuron activity and the consequent mesoscale output. The development of cranial window technologies, in which the skull is thinned or replaced with a synthetic optical interface, has enabled monitoring neuronal activity from subcellular to mesoscale resolution in awake, behaving animals when coupled with advanced microscopy techniques. Here we review recent achievements in cranial window technologies, appraise the relative merits of each design and discuss the future research in cranial window design.
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影响因子:
25
作者:
Chow, David K.;Groszer, Matthias;Pribadi, Mochtar;Machniki, Michal;Carmichael, S. Thomas;Liu, Xin;Trachtenberg, Joshua T.
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