Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?
Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?
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DOI：
10.1016/j.neubiorev.2012.03.005
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发表时间：
2012-05
影响因子：
8.2
通讯作者：
Allen PJ
中科院分区：
文献类型：
--
作者：
Allen PJ
运动员、健美运动员和军事人员使用膳食肌酸作为增能辅助剂，以提高涉及短时间高强度肌肉活动的运动中的身体表现。较少为人所知的是肌酸，一种能量稳态的天然调节剂，在大脑功能和发育中发挥的重要作用。肌酸补充剂已显示出作为用于治疗与能量代谢功能障碍相关的脑相关疾病（如亨廷顿病和帕金森病）的药物的安全、有效和可耐受的辅助剂的前景。肌酸代谢障碍也与精神疾病的发病机制有关，这让临床医生、研究人员和患者都想知道饮食肌酸是否对治疗精神疾病具有治疗价值。本文综述了肌酸磷酸肌酸回路的神经生物学及其与心理应激、精神分裂症、心境和焦虑障碍的关系。虽然肌酸在认知和情绪处理中的作用目前的知识还处于起步阶段，但对这种内源性代谢物的进一步研究有可能促进我们对精神病理学生物学基础的理解，并改善目前的治疗策略。
Athletes, body builders, and military personnel use dietary creatine as an ergogenic aid to boost physical performance in sports involving short bursts of high-intensity muscle activity. Lesser known is the essential role creatine, a natural regulator of energy homeostasis, plays in brain function and development. Creatine supplementation has shown promise as a safe, effective, and tolerable adjunct to medication for the treatment of brain-related disorders linked with dysfunctional energy metabolism, such as Huntington’s Disease and Parkinson’s Disease. Impairments in creatine metabolism have also been implicated in the pathogenesis of psychiatric disorders, leaving clinicians, researchers and patients alike wondering if dietary creatine has therapeutic value for treating mental illness. The present review summarizes the neurobiology of the creatine-phosphocreatine circuit and its relation to psychological stress, schizophrenia, mood and anxiety disorders. While present knowledge of the role of creatine in cognitive and emotional processing is in its infancy, further research on this endogenous metabolite has the potential to advance our understanding of the biological bases of psychopathology and improve current therapeutic strategies.
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