Tumor detection with transoral use of flexible endoscopy for unknown primary head and neck cancer.
Tumor detection with transoral use of flexible endoscopy for unknown primary head and neck cancer.
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DOI：
10.1002/lio2.656
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发表时间：
2021-10
影响因子：
1.9
通讯作者：
Okami K
中科院分区：
文献类型：
--
作者：
Ebisumoto K;Sakai A;Maki D;Robinson K;Murakami T;Iijima H;Yamauchi M;Saito K;Watanabe T;Okami K
随着新的光学技术的出现，早期咽喉癌病变可以更好地可视化。虽然传统的经鼻入路提供了下咽和喉的良好视野，但口咽和腭扁桃体的可视化有限。通过经口插入柔性视频喉镜，可以获得口咽和口腔的直接视图。因此，经口检查可能有助于原发性不明癌症（CUP）的初步检测。本研究回顾性纳入了2006年至2017年来自东海大学的85例CUP患者。从2010年开始，除了传统的方法外，我们还采用了经口检查。比较2010年前后的初检率。进一步分析口咽原发灶的肿瘤亚位点和p16状态。总体初步检出率并没有随着经口检查的增加而提高。然而，更多的口咽初级检测。口咽部病变以p16阳性为主，位于腭扁桃体。经口检查是一种非侵入性的，易于在门诊环境中采用的方法，并且是一种有前途的技术，可以改善人类乳头状瘤病毒相关头颈部癌症时代的肿瘤检测。3.
With the advent of new optical technologies, early pharyngolaryngeal cancerous lesions can be better visualized. Although the conventional transnasal approach offers great views of the hypopharynx and larynx, the visualization of the oropharynx and palatine tonsils is limited. Through the transoral insertion of a flexible video‐laryngoscope, direct views of the oropharynx and oral cavity can be obtained. Thus, transoral examination may contribute to primary detection of cancers of unknown primary (CUP). Eighty‐five CUP patients from Tokai University were included retrospectively in this study, from 2006 to 2017. Starting in 2010, we employed the transoral examination in addition to our conventional method. The primary detection rates were compared before and after 2010. Oropharyngeal primaries were further analyzed for tumor subsite and p16 status. The overall primary detection rate did not improve with the addition of transoral examination. However, greater numbers of oropharyngeal primaries were detected. The oropharyngeal lesions detected by transoral examination were mainly p16 positive, located on the palatine tonsil. Transoral examination is a noninvasive, easy method to adopt in an outpatient setting, and a promising technique to improve tumor detection in this era of human papillomavirus‐associated head and neck cancers. 3.
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