Organic anion transporting polypeptides expressed in pancreatic cancer may serve as potential diagnostic markers and therapeutic targets for early stage adenocarcinomas.
Organic anion transporting polypeptides expressed in pancreatic cancer may serve as potential diagnostic markers and therapeutic targets for early stage adenocarcinomas.
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DOI：
10.1007/s11095-012-0962-7
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发表时间：
2013-09
影响因子：
3.7
通讯作者：
Hagenbuch, Bruno
中科院分区：
文献类型：
--
作者：
Hays, Amanda;Apte, Udayan;Hagenbuch, Bruno
有机阴离子转运多肽（OATP）在体内各种上皮组织中表达。因为它们可以在癌症中表达，并且因为它们可以转运抗癌药物，所以OATPs可能是癌症治疗的潜在靶点。因此，我们研究了它们在人胰腺导管腺癌中的表达。在mRNA水平测量所有11种人OATP的表达，并在蛋白质水平表征具有最高表达的OATP。在所有受试胰腺组织中均检测到SLCO 1B3、SLCO 2A1、SLCO 3A1和SLCO 4A1的转录本。在这些组织中证实了OATP1B3、OATP2A1、OATP3A1和OATP4A1蛋白表达，与正常胰腺相比，胰腺癌中所有四种转运蛋白的表达均增加。OATP1B3表达在胰腺增生和1期腺癌中最高，而在2期和3期腺癌中最低。OATP1B3、OATP2A1、OATP3A1和OATP4A1在胰腺癌中上调，可能用于靶向胰腺癌的抗癌药物。此外，由于OATP1B3在胰腺炎和导致胰腺癌的一期腺癌中表达最高，因此OATP1B3是诊断早期胰腺腺癌患者的潜在标志物。
Organic Anion Transporting Polypeptides (OATPs) are expressed in various epithelial tissues in the body. Because they can be expressed in cancers and because they can transport anticancer drugs, OATPs could be potential targets for cancer therapy. Therefore we examined their expression in human pancreatic ductal adenocarcinomas. Expression of all eleven human OATPs was measured at the mRNA level and OATPs with highest expression were characterized at the protein level. Transcripts of SLCO1B3, SLCO2A1, SLCO3A1 and SLCO4A1 were detected in all the tested pancreatic tissues. OATP1B3, OATP2A1, OATP3A1 and OATP4A1 protein expression was confirmed in these tissues and expression of all four transporters increased in pancreatic adenocarcinoma compared to normal pancreas. OATP1B3 expression was highest in pancreatic hyperplasia and stage one adenocarcinomas compared to stage two and three adenocarcinomas. OATP1B3, OATP2A1, OATP3A1 and OATP4A1 are up-regulated in pancreatic adenocarcinoma and could potentially be used to target anticancer drugs to pancreatic cancer. Additionally, because expression of OATP1B3 is highest in pancreatitis and stage one adenocarcinoma, which leads to pancreatic cancer, OATP1B3 is a potential marker to diagnose patients with early stage pancreatic adenocarcinomas.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
4.8
作者：
König, J;Cui, YH;Keppler, D
通讯作者：
Keppler, D
影响因子：
5.8
作者：
Pizzagalli, F;Varga, Z;St-Pierre, MV
通讯作者：
St-Pierre, MV
影响因子：
4.5
作者：
Hagenbuch, B;Meier, PJ
通讯作者：
Meier, PJ
DOI：
10.1124/jpet.104.071522
发表时间：
2004-12-01
影响因子：
3.5
作者：
Nozawa, T;Suzuki, M;Tamai, I
通讯作者：
Tamai, I