Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation.
Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multimodal imaging investigation.
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年轻成人 APOE-ε4 携带者后默认模式网络活动和结构连接性增加：多模态成像研究。
DOI：
10.1016/j.neurobiolaging.2018.08.026
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发表时间：
2019-01
影响因子：
4.2
通讯作者：
Graham KS
中科院分区：
文献类型：
--
作者：
Hodgetts CJ;Shine JP;Williams H;Postans M;Sims R;Williams J;Lawrence AD;Graham KS
Young adult APOE-ε4 carriers show increased activity in posterior regions of the default mode network (pDMN), but how this is related to structural connectivity is unknown. Thirty young adults (one half of whom were APOE-ε4 carriers; mean age 20 years) were scanned using both diffusion and functional magnetic resonance imaging. The parahippocampal cingulum bundle (PHCB)—which links the pDMN and the medial temporal lobe—was manually delineated in individual participants using deterministic tractography. Measures of tract microstructure (mean diffusivity and fractional anisotropy) were then extracted from these tract delineations. APOE-ε4 carriers had lower mean diffusivity and higher fractional anisotropy relative to noncarriers in PHCB, but not in a control tract (the inferior longitudinal fasciculus). Furthermore, PHCB microstructure was selectively associated with pDMN (and medial temporal lobe) activity during a scene discrimination task known to be sensitive to Alzheimer's disease. These findings are consistent with a lifespan view of Alzheimer's disease risk, where early-life, connectivity-related changes in specific, vulnerable “hubs” (e.g., pDMN) lead to increased neural activity. Critically, such changes may reflect reduced network efficiency/flexibility in APOE-ε4 carriers, which in itself may portend a faster decline in connectivity over the lifespan and ultimately trigger early amyloid-β deposition in later life.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
Stam CJ
DOI：
10.1523/jneurosci.5845-11.2012
发表时间：
2012-03-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bero AW;Bauer AQ;Stewart FR;White BR;Cirrito JR;Raichle ME;Culver JP;Holtzman DM
通讯作者：
Holtzman DM
DOI：
10.1016/j.jalz.2009.07.003
发表时间：
2010-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Dennis NA;Browndyke JN;Stokes J;Need A;Burke JR;Welsh-Bohmer KA;Cabeza R
通讯作者：
Cabeza R
DOI：
10.1523/jneurosci.0305-12.2012
发表时间：
2012-06-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Damoiseaux JS;Seeley WW;Zhou J;Shirer WR;Coppola G;Karydas A;Rosen HJ;Miller BL;Kramer JH;Greicius MD;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
3.3
作者：
Habib, Josef;Auer, Dorothee P.;Morgan, Paul S.
通讯作者：
Morgan, Paul S.