Nanoparticle-assisted, image-guided laser interstitial thermal therapy for cancer treatment.
Nanoparticle-assisted, image-guided laser interstitial thermal therapy for cancer treatment.
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DOI：
10.1002/wnan.1826
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发表时间：
2022-09
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影响因子：
--
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磁共振引导下的激光间质热疗(LIT)是治疗脑肿瘤和非中枢神经系统肿瘤的一种新方法。MRI引导允许在肿瘤内精确放置光纤，而MR温度计在手术过程中提供实时监测和评估热剂量。尽管临床结果很有希望，但与脑肿瘤手术相关的微小并发症，如出血、水肿、癫痫发作和对附近健康组织的热损伤，仍然是一个重要的问题。为了解决这些并发症，纳米颗粒为精确的间质热疗应用提供了独特的前景，可以增加肿瘤内的热传输，同时减少对邻近健康组织的热影响。此外，纳米颗粒允许联合传递治疗化合物，不仅与LITT协同，而且还可以提高整体有效性和安全性。此外，具有独特光学性质的高效生热纳米颗粒可以通过改进的实时成像和热传感来增强LITT的治疗。这篇综述将集中在(1)用于LITT的无机和有机纳米颗粒的类型；(2)研究纳米颗粒对光-组织相互作用的影响的体外、硅学和体外研究；以及(3)纳米颗粒制剂在推进LITT临床相关图像引导技术中的作用。神经疾病的治疗方法和药物发现&神经疾病的纳米医学可植入材料和外科技术>；外科中的纳米工具和技术本文被归类为：设想的激光间质热疗的临床治疗范例。设想的临床治疗范例建立在新的和已建立的神经外科工作流程的基础上，能够在活组织检查、活组织检查后或LITT程序之前通过瘤内注射简化纳米颗粒输注。纳米颗粒输注后，术中基于成像的反馈和基于LITT MRI的反馈可以用于改善成像、热感应和增强治疗。热数据图像(Medvid等人，2015)。
Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non‐central nervous system (non‐CNS) tumors. MRI guidance allows for precise placement of optical fiber in the tumor, while MR thermometry provides real‐time monitoring and assessment of thermal doses during the procedure. Despite promising clinical results, LITT complications relating to brain tumor procedures, such as hemorrhage, edema, seizures, and thermal injury to nearby healthy tissues, remain a significant concern. To address these complications, nanoparticles offer unique prospects for precise interstitial hyperthermia applications that increase heat transport within the tumor while reducing thermal impacts on neighboring healthy tissues. Furthermore, nanoparticles permit the co‐delivery of therapeutic compounds that not only synergize with LITT, but can also improve overall effectiveness and safety. In addition, efficient heat‐generating nanoparticles with unique optical properties can enhance LITT treatments through improved real‐time imaging and thermal sensing. This review will focus on (1) types of inorganic and organic nanoparticles for LITT; (2) in vitro, in silico, and ex vivo studies that investigate nanoparticles' effect on light–tissue interactions; and (3) the role of nanoparticle formulations in advancing clinically relevant image‐guided technologies for LITT. Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery This article is categorized under: Envisioned clinical treatment paradigm of laser interstitial thermal therapy (LITT). The envisioned clinical treatment paradigm builds from new and established neurosurgical workflows that enables streamlined nanoparticle infusion via intratumoral delivery during biopsy, post biopsy, or right before LITT procedures. Post nanoparticle infusion, intraoperative imaging‐based feedback and intra‐LITT MRI‐based feedback can be leveraged for improved imaging, thermal sensing, and enhanced treatment. Thermal data image from (Medvid et al., 2015).
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发表时间：
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影响因子：
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