Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis.
Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis.
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通过单细胞分析对当前乳腺癌微环境进展的综合描述
DOI：
10.1186/s13046-021-01949-z
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发表时间：
2021-04-27
期刊：
影响因子：
--
通讯作者：
Yin Y
中科院分区：
文献类型：
--
作者：
Yan X;Xie Y;Yang F;Hua Y;Zeng T;Sun C;Yang M;Huang X;Wu H;Fu Z;Li W;Jiao S;Yin Y
乳腺癌是一种异质性疾病，其复杂的微环境由肿瘤细胞、免疫细胞、成纤维细胞和血管细胞组成。这些与癌症相关的细胞塑造了肿瘤微环境（TME），并影响乳腺癌的进展以及患者的治疗反应。由于肿瘤微环境具有高度的异质性和动态性，肿瘤内细胞的确切组成是复杂的。单细胞技术的最新进展，如单细胞DNA测序（scDNA - seq）、单细胞RNA测序（scRNA - seq）和质谱流式细胞技术，为乳腺癌中肿瘤浸润细胞的表型和功能多样性提供了新的见解。在这篇综述中，我们概述了乳腺肿瘤生态系统单细胞特征描述的最新进展，并总结了肿瘤内细胞的表型多样性及其潜在的预后相关性。
Breast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment (TME) and influence the progression of breast cancer and the therapeutic responses in patients. The exact composition of the intra-tumoral cells is mixed as the highly heterogeneous and dynamic nature of the TME. Recent advances in single-cell technologies such as single-cell DNA sequencing (scDNA-seq), single-cell RNA sequencing (scRNA-seq) and mass cytometry have provided new insights into the phenotypic and functional diversity of tumor-infiltrating cells in breast cancer. In this review, we have outlined the recent progress in single-cell characterization of breast tumor ecosystems, and summarized the phenotypic diversity of intra-tumoral cells and their potential prognostic relevance.
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影响因子：
6.4
作者：
Collin M;Bigley V
通讯作者：
Bigley V
影响因子：
64.8
作者：
通讯作者：
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影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
10.1
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Cremasco V;Astarita JL;Grauel AL;Keerthivasan S;MacIsaac K;Woodruff MC;Wu M;Spel L;Santoro S;Amoozgar Z;Laszewski T;Migoni SC;Knoblich K;Fletcher AL;LaFleur M;Wucherpfennig KW;Pure E;Dranoff G;Carroll MC;Turley SJ
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Turley SJ
影响因子：
50.3
作者：
Costa, Ana;Kieffer, Yann;Mechta-Grigoriou, Fatima
通讯作者：
Mechta-Grigoriou, Fatima