Effects of Diabetes and Voluntary Exercise on IgA Concentration and Polymeric Immunoglobulin Receptor Expression in the Submandibular Gland of Rats.
Effects of Diabetes and Voluntary Exercise on IgA Concentration and Polymeric Immunoglobulin Receptor Expression in the Submandibular Gland of Rats.
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DOI：
10.3390/medicina59040789
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发表时间：
2023-04-18
期刊：
影响因子：
--
通讯作者：
Tsukinoki K
中科院分区：
文献类型：
--
作者：
Park J;Yamamoto Y;Hidaka K;Wada-Takahashi S;Takahashi SS;Morozumi T;Kubota N;Saita M;Saruta J;Sakaguchi W;To M;Shimizu T;Mikuni-Takagaki Y;Tsukinoki K
背景和目的：糖尿病患者更易发生上呼吸道感染，因为他们容易感染。唾液免疫球蛋白A(sALI-IgA)水平在尿路感染的传播中起主要作用。SALI-IgA水平由唾液腺产生的IgA和聚合免疫球蛋白受体(Poly-IGR)的表达决定。然而，目前尚不清楚糖尿病患者唾液腺IgA的产生和PolyIGR的表达是否减少。虽然据报道，运动可以增加或降低sALI-IgA水平，但运动如何影响糖尿病患者的唾液腺尚不清楚。本研究旨在确定糖尿病和自愿运动对糖尿病大鼠唾液腺中IgA产生和多聚IGR表达的影响。材料和方法：10只8周龄自发性糖尿病大鼠OLETF(Otsuka Long-Evans Tokushima Fatty，OLETF)，随机分为非运动组(OLETF-C)和自愿轮跑组(OLETF-E)，每组5只。5只无糖尿病的Long-Evans Tokushima Otsuka(LETO)大鼠在与OLETF-C相同的条件下饲养。研究开始16周后，收集颌下腺(SGS)，并分析IgA和PolyIGR的表达水平。结果：OLETF-C和OLETF-E组SGS的IgA浓度和PolyIGR表达水平均低于LETO组(p<；0.05)。这些值在OLETF-C和OLETF-E之间没有差别。结论：糖尿病降低了大鼠唾液腺中IgA的产生和多聚IGR的表达。此外，自愿运动增加了sALI-IgA水平，但不增加糖尿病大鼠唾液腺中IgA的产生和多聚IGR的表达。增加唾液腺中IgA的产生和多聚IGR的表达，可能需要比医生监督下的自愿锻炼略高的运动强度。
Background and Objectives: Patients with diabetes are more susceptible to upper respiratory tract infections (URTIs) because they are easily infected. Salivary IgA (sali-IgA) levels play a major role in transmitting URTIs. Sali-IgA levels are determined by salivary gland IgA production and polymeric immunoglobulin receptor (poly-IgR) expression. However, it is unknown whether salivary gland IgA production and poly-IgR expression are decreased in patients with diabetes. While exercise is reported to increase or decrease the sali-IgA levels, it is unclear how exercise affects the salivary glands of patients with diabetes. This study aimed to determine the effects of diabetes and voluntary exercise on IgA production and poly-IgR expression in the salivary glands of diabetic rats. Materials and Methods: Ten spontaneously diabetic Otsuka Long–Evans Tokushima Fatty (OLETF) rats (eight-week-old) were divided into two groups of five rats each: a non-exercise group (OLETF-C) and a voluntary wheel-running group (OLETF-E). Five Long–Evans Tokushima Otsuka (LETO) rats without diabetes were bred under the same conditions as the OLETF-C. Sixteen weeks after the study began, the submandibular glands (SGs) were collected and analyzed for IgA and poly-IgR expression levels. Results: IgA concentrations and poly-IgR expression levels in SGs were lower in OLETF-C and OLETF-E than in LETO (p < 0.05). These values did not differ between the OLETF-C and OLETF-E. Conclusions: Diabetes decreases IgA production and poly-IgR expression in the salivary glands of rats. Moreover, voluntary exercise increases sali-IgA levels but does not increase IgA production and poly-IgR expression in the salivary glands of diabetic rats. Increasing IgA production and poly-IgR expression in the salivary glands, which is reduced in diabetes, might require slightly higher-intensity exercise than voluntary exercise under the supervision of a doctor.
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作者：
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通讯作者：
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作者：
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