Effect of High Fat and Fructo-Oligosaccharide Consumption on Immunoglobulin A in Saliva and Salivary Glands in Rats.

Effect of High Fat and Fructo-Oligosaccharide Consumption on Immunoglobulin A in Saliva and Salivary Glands in Rats.
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DOI:
10.3390/nu13041252
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发表时间:
2021-04-10
期刊:
影响因子:
5.9
通讯作者:
Tsukinoki K
Tsukinoki K
中科院分区:
医学2区
文献类型:
--
作者:
Yamamoto Y;Morozumi T;Takahashi T;Saruta J;Sakaguchi W;To M;Kubota N;Shimizu T;Kamata Y;Kawata A;Tsukinoki K

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食用不可消化的膳食纤维会增加唾液中免疫球蛋白 A (IgA) 的水平。本研究的目的是阐明摄入大量脂肪和难消化膳食纤维对唾液和颌下腺 (SMG) 中 IgA 水平的协同作用。 7周龄Wistar大鼠饲喂低脂(60 g/kg)无纤维饮食、低脂低聚果糖(FOS,30 g/kg)饮食、高脂(220 g/kg)无纤维饮食或高脂FOS饮食70天。低脂 FOS 组的唾液 IgA 流速(IgA FR-唾液)高于其他组 (p < 0.05)。此外,与其他组相比,低脂 FOS 组 SMG 中酪氨酸羟化酶(交感神经激活标志物)的浓度较高(p < 0.05),并且与 IgA FR 唾液呈正相关(rs = 0.68。p < 0.0001。n = 32)。这些发现表明,在摄入低脂低聚果糖期间,唾液 IgA 水平可能通过交感神经激活而增加。
Consumption of indigestible dietary fiber increases immunoglobulin A (IgA) levels in saliva. The purpose of this study is to clarify the synergistic effect of the intake of a high amount of fats and indigestible dietary fiber on IgA levels in saliva and submandibular glands (SMG). Seven-week-old Wistar rats were fed a low-fat (60 g/kg) fiberless diet, low-fat fructo-oligosaccharide (FOS, 30 g/kg) diet, high-fat (220 g/kg) fiberless diet, or high-fat FOS diet for 70 days. The IgA flow rate of saliva (IgA FR-saliva) was higher in the low-fat FOS group than in the other groups (p < 0.05). Furthermore, the concentration of tyrosine hydroxylase (a marker of sympathetic nerve activation) in the SMG was higher in the low-fat FOS group (p < 0.05) and positively correlated with the IgA FR-saliva (rs = 0.68. p < 0.0001. n = 32) in comparison to that in the other groups. These findings suggest that during low-fat FOS intake, salivary IgA levels may increase through sympathetic nerve activation.
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