The human spongiform encephalopathies: kuru, Creutzfeldt-Jakob disease, and the Gerstmann-Sträussler-Scheinker syndrome.
The human spongiform encephalopathies: kuru, Creutzfeldt-Jakob disease, and the Gerstmann-Sträussler-Scheinker syndrome.
复制标题
人类海绵状脑病：库鲁病、克雅氏病和 Gerstmann-Sträussler-Scheinker 综合征。
DOI：
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发表时间：
1991
影响因子：
--
通讯作者：
D. Gajdusek
中科院分区：
文献类型：
--
作者：
P. Brown;D. Gajdusek
库鲁病和传染性病毒性痴呆、克雅氏病（CJD）和Gerstmann-Straussler-Scheinker综合征（GSS）属于病毒诱导的慢性感染，我们将其描述为亚急性海绵状病毒性脑病，因为它们诱导的组织病理学病变惊人相似（表1）。羊瘙痒病、水貂脑病、圈养骡鹿和圈养麋鹿的慢性消耗性海绵状脑病和牛海绵状脑病从其组织病理学、发病机制和病原体的相似性来看都属于同一组。所有这些疾病的基本神经细胞学病变是神经元的树突和轴突过程和细胞体中的进行性空泡化，在较小程度上，星形胶质细胞和少突胶质细胞;广泛的星形胶质细胞肥大和增殖;以及灰质的海绵状变化或海绵状状态，伴有广泛的神经元损失。
Kuru and the transmissible virus dementias Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler-Scheinker syndrome (GSS) belong to the group of virus-induced slow infections that we have described as subacute spongiform virus encephalopathies because of the strikingly similar histopathological lesions they induce (Table 1). Scrapie, mink encephalopathy, chronic wasting disease with spongiform encephalopathy of captive mule deer and of captive elk, and bovine spongiform encephalopathy all appear from their histopathology, pathogenesis, and the similarities of their infectious agents to belong to the same group. The basic neurocytological lesions in all these diseases are a progressive vacuolation in the dendritic and axonal processes and cell bodies of neurons and, to a lesser extent, astrocytes and oligodendrocytes; an extensive astroglial hypertrophy and proliferation; and spongiform change or status spongiosis of gray matter with extensive neuronal loss.
来自非常规慢病毒疾病的感染特异性颗粒。
DOI：
10.1126/science.6377496
发表时间：
1984
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Merz,PA;Rohwer,RG;Kascsak,R;Wisniewski,HM;Somerville,RA;GibbsJr,CJ;Gajdusek,DC
通讯作者：
Gajdusek,DC