Is there a need for emerging drugs for the acute respiratory distress syndrome?

Is there a need for emerging drugs for the acute respiratory distress syndrome?
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DOI:
10.1517/14728214.2014.953052
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发表时间:
2014-09
影响因子:
3.4
通讯作者:
Matthay M
Matthay M
中科院分区:
医学3区
文献类型:
--
作者:
Fitzgerald M;McAuley DF;Matthay M

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急性呼吸窘迫综合征(ARDS)是一种常见的急性呼吸衰竭综合征,目前尚无有效的药物治疗方法。作者描述了一些有希望作为这种情况的潜在治疗方法的干预措施,特别是参考了临床相关的ARDS人类模型。阿司匹林,间充质间质(干细胞)细胞,角化细胞生长因子,IFN-β和抑癌素M抑制进行了讨论。
The acute respiratory distress syndrome (ARDS) is a common and devastating syndrome of acute respiratory failure for which little effective pharmacotherapy exists. The authors describe some interventions that show promise as potential therapies for this condition, with particular reference to clinically relevant human models of ARDS. Aspirin, mesenchymal stromal (stem) cells, keratinocyte growth factor, IFN-β and oncostatin M inhibition are discussed.
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