Intra-amniotic inflammation and child neurodevelopment: a systematic review protocol.
Intra-amniotic inflammation and child neurodevelopment: a systematic review protocol.
复制标题
肿瘤内炎症和儿童神经发育：系统审查方案。
DOI：
10.1186/s13643-018-0683-z
复制
发表时间：
2018-01-22
影响因子：
3.7
通讯作者：
Boutin A
中科院分区：
文献类型：
--
作者：
Soucy-Giguère L;Gasse C;Giguère Y;Demers S;Bujold E;Boutin A
羊膜内炎症与不良妊娠和新生儿结局相关。然而，对儿童神经发育的影响仍不清楚。我们的目的是评估羊膜内炎症对儿童神经发育结果的影响。将检索数据库MEDLINE、Embase、CINAHL和科克伦，从其开始到2017年11月。随机试验和队列研究，其中炎性标志物测量羊水收集羊水穿刺术和婴儿的神经发育进行了评估将是合格的。两名评审员将独立选择合格的研究，评估其偏倚风险并提取数据。将比较结果，如有分歧，将咨询第三方。我们感兴趣的主要结果是儿童神经发育，通过有效的工具或修订病历进行评估。次要结局将包括异常脑成像。将合并相对风险，并对子宫穿刺术的适应症、子宫穿刺术时的胎龄、分娩时的胎龄和胎儿性别进行敏感性分析。偏倚风险将使用科克伦协作组的随机试验偏倚风险评估工具或非随机研究偏倚风险评估的ROBINS-1改编版本进行评估。这篇系统性综述将报告目前关于羊膜炎和儿童神经发育之间相关性的证据，以及这种相关性的修饰剂。该综述将产生关于病理通路的新假设，并将指导未来的研究。PROSPERO 2017 65065本文的在线版本（10.1186/s13643-018-0683-z）包含补充材料，可供授权用户使用。
Intra-amniotic inflammation is associated with adverse pregnancy and neonatal outcomes. However, the impact on child neurodevelopment remains unclear. We aim to assess the effect of intra-amniotic inflammation on neurodevelopmental outcomes in children. The databases MEDLINE, Embase, CINAHL, and Cochrane will be searched from their inception until November 2017. Randomized trials and cohort studies in which inflammatory markers were measured in amniotic fluid collected by amniocentesis and in which infant’s neurodevelopment was assessed will be eligible. Two reviewers will independently select eligible studies, assess their risk of bias, and extract data. Results will be compared and a third party will be consulted in case of disagreement. Our primary outcome of interest is child neurodevelopment, assessed with either a validated tool or by revision of medical records for specific diagnosis. Secondary outcomes will include abnormal brain imaging. Relative risks will be pooled and sensitivity analyses will be performed for the indication of amniocentesis, gestational age at amniocentesis, gestational age at delivery, and fetal sex. Risk of bias will be assessed using the Cochrane Collaboration’s tool for assessing the risk of bias in randomized trials or an adapted version of the ROBINS-1 for the risk of bias in non-randomized studies. This systematic review will report the current evidence regarding the association between amniotic inflammation and child neurodevelopment, and the modifiers of this association. The review will generate new hypotheses on pathological pathways and will guide future research. PROSPERO 2017 65065 The online version of this article (10.1186/s13643-018-0683-z) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.3109/14767058.2015.1094049
发表时间：
2016
期刊：
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
影响因子：
--
作者：
Kim SM;Romero R;Lee J;Chaemsaithong P;Lee MW;Chaiyasit N;Lee HJ;Yoon BH
通讯作者：
Yoon BH
DOI：
10.3109/14767058.2014.958463
发表时间：
2015-08
期刊：
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
影响因子：
--
作者：
Romero R;Miranda J;Chaemsaithong P;Chaiworapongsa T;Kusanovic JP;Dong Z;Ahmed AI;Shaman M;Lannaman K;Yoon BH;Hassan SS;Kim CJ;Korzeniewski SJ;Yeo L;Kim YM
通讯作者：
Kim YM
影响因子：
3.7
作者：
Moher D;Shamseer L;Clarke M;Ghersi D;Liberati A;Petticrew M;Shekelle P;Stewart LA;PRISMA-P Group
通讯作者：
PRISMA-P Group
影响因子：
2.4
作者：
Kasper, David C.;Mechtler, Thomas P.;Berger, Angelika
通讯作者：
Berger, Angelika
DOI：
10.1111/j.1471-0528.2009.02364.x
发表时间：
2009-12-01
影响因子：
5.8
作者：
Daskalakis, G.;Thomakos, N.;Antsaklis, A.
通讯作者：
Antsaklis, A.