Impact of Fiber Structure on the Material Stability and Rupture Mechanisms of Coronary Atherosclerotic Plaques.
Impact of Fiber Structure on the Material Stability and Rupture Mechanisms of Coronary Atherosclerotic Plaques.
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DOI：
10.1007/s10439-017-1827-3
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发表时间：
2017-06
影响因子：
3.8
通讯作者：
Teng Z
中科院分区：
文献类型：
--
作者：
Douglas GR;Brown AJ;Gillard JH;Bennett MR;Sutcliffe MPF;Teng Z
冠状动脉循环中动脉粥样硬化斑块的破裂仍然是心脏病发作的主要原因。作为纤维取向的结构，纤维结构，特别是在纤维帽（FC）中的纤维结构，可以影响板中的负载和材料强度。然而，纤维取向和分散在斑块破裂中的作用尚不清楚。从16个人冠状动脉粥样硬化病变的组织学图像中计算肩部区域、FC中部和内膜增厚（IT）区域的纤维局部取向和分散。进行有限元分析，以评估这些性能对机械条件的影响。与FC中部（6.1° [5.5，9.0]）和IT区域（6.7° [5.1，8.6]）相比，肩部区域的纤维排列明显减少（中位数[四分位距] 12.9° [6.6，18.0]，p < 0.05）。纤维分散在肩部最高（0.150 [0.121，0.192]），IT居中（0.119 [0.103，0.144]），FC中部最低（0.093 [0.081，0.105]，p < 0.05）。当考虑各向异性特性时，中部FC（p = 0.030）和IT区域（p = 0.002）的应力显著较高，肩关节或整体区域无差异。各区域纤维之间的剪（滑动）应力及其占最大主应力的比例分别为：肩部（25.8 kPa [17.1，41.2]，12.4%）、中部FC（13.9 kPa [5.8，29.6]，13.8%）和IT（36.5 kPa [25.9，47.3]，15.5%）。FC内的纤维结构对主应力有显著的影响，导致纤维之间产生相当大的剪应力。纤维结构（包括取向和分散）可以决定动脉粥样硬化斑块的机械强度，从而决定斑块的破裂。本文的在线版本（doi：10.1007/s10439-017-1827-3）包含补充材料，可供授权用户使用。
The rupture of an atherosclerotic plaque in the coronary circulation remains the main cause of heart attack. As a fiber-oriented structure, the fiber structure, in particular in the fibrous cap (FC), may affect both loading and material strength in the plaque. However, the role of fiber orientation and dispersion in plaque rupture is unclear. Local orientation and dispersion of fibers were calculated for the shoulder regions, mid FC, and regions with intimal thickening (IT) from histological images of 16 human coronary atherosclerotic lesions. Finite element analysis was performed to assess the effect of these properties on mechanical conditions. Fibers in shoulder regions had markedly reduced alignment (Median [interquartile range] 12.9° [6.6, 18.0], p < 0.05) compared with those in mid FC (6.1° [5.5, 9.0]) and IT regions (6.7° [5.1, 8.6]). Fiber dispersion was highest in shoulders (0.150 [0.121, 0.192]), intermediate in IT (0.119 [0.103, 0.144]), and lowest in mid FC regions (0.093 [0.081, 0.105], p < 0.05). When anisotropic properties were considered, stresses were significantly higher for the mid FC (p = 0.030) and IT regions (p = 0.002) and no difference was found for the shoulder or global regions. Shear (sliding) stress between fibers in each region and their proportion of maximum principal stress were: shoulder (25.8 kPa [17.1, 41.2], 12.4%), mid FC (13.9 kPa [5.8, 29.6], 13.8%), and IT (36.5 kPa [25.9, 47.3], 15.5%). Fiber structure within the FC has a marked effect on principal stresses, resulting in considerable shear stress between fibers. Fiber structure including orientation and dispersion may determine mechanical strength and thus rupture of atherosclerotic plaques. The online version of this article (doi:10.1007/s10439-017-1827-3) contains supplementary material, which is available to authorized users.
影响因子：
3.7
作者：
Teng Z;Sadat U;Wang W;Bahaei NS;Chen S;Young VE;Graves MJ;Gillard JH
通讯作者：
Gillard JH