Intraplaque stretch in carotid atherosclerotic plaque--an effective biomechanical predictor for subsequent cerebrovascular ischemic events.
Intraplaque stretch in carotid atherosclerotic plaque--an effective biomechanical predictor for subsequent cerebrovascular ischemic events.
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DOI：
10.1371/journal.pone.0061522
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Gillard JH
中科院分区：
文献类型：
--
作者：
Teng Z;Sadat U;Wang W;Bahaei NS;Chen S;Young VE;Graves MJ;Gillard JH
拉伸是一个力学参数，以前已经提出影响不同组织中的生物活性。本研究探讨了其在确定斑块易损性中的实用性。本研究招募了106例轻度至中度颈动脉狭窄患者（53例有症状，53例无症状）。高分辨率，多序列磁共振（MR）成像进行描绘各种斑块成分。有限元法用于预测斑块内的高拉伸浓度。随访2年，有症状组11例，无症状组3例复发脑血管事件。有症状组收缩期斑块的伸展性和一个心动周期内的伸展性变化均大于无症状组。在有症状组中，与无复发事件的患者相比，在复发事件的患者中观察到相似的趋势。具有高拉伸浓度和大拉伸变化的斑块与未来脑血管事件的风险增加相关。
Stretch is a mechanical parameter, which has been proposed previously to affect the biological activities in different tissues. This study explored its utility in determining plaque vulnerability. One hundred and six patients with mild to moderate carotid stenosis were recruited in this study (53 symptomatic and 53 asymptomatic). High resolution, multi-sequence magnetic resonance (MR) imaging was performed to delineate various plaque components. Finite element method was used to predict high stretch concentration within the plaque. During a two-year follow-up, 11 patients in symptomatic group and 3 in asymptomatic group experienced recurrent cerebrovascular events. Plaque stretch at systole and stretch variation during one cardiac cycle was greater in symptomatic group than those in the asymptomatic. Within the symptomatic group, a similar trend was observed in patients with recurrent events compared to those without. Plaques with high stretch concentration and large stretch variation are associated with increased risk of future cerebrovascular events.
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影响因子：
14
作者：
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通讯作者：
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影响因子：
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