Minireview Defence against antimicrobial peptides: different strategies in Firmicutes
Minireview Defence against antimicrobial peptides: different strategies in Firmicutes
复制标题
小型综述防御抗菌肽：厚壁菌门的不同策略
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
M. Zúñiga
中科院分区：
文献类型：
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作者：
Ainhoa Revilla;S. Gebhard;T. Mascher;M. Zúñiga
厚壁菌门是一门细菌，可以在各种各样的栖息地中找到，从土壤到动物的胃肠道，它们必须在复杂的群落中茁壮成长。这些群落中的竞争通常涉及产生诸如抗菌肽（AMPs）之类的化合物以消除竞争生物。动物和植物也产生抗菌肽来控制其相关的微生物群。反过来，防御机制已经进化到阻止这些化合物的作用。一些厚壁菌门作为突出的病原体或共生生物与人类密切相关，这促使人们对这些细菌对抗抗菌化合物的防御机制进行了大量的研究。本文综述了两种具有良好特征的抗amp防御机制的最新进展：d -丙烯酰化修饰细胞壁和肽抗生素特异性腺苷三磷酸结合盒转运体的作用。
The Firmicutes constitute a phylum of bacteria that can be found in a wide variety of habitats, from soil to the gastrointestinal tract of animals, where they have to thrive in complex communities. Competition in these communities usually involves the production of compounds such as antimicrobial peptides (AMPs) to eliminate competitor organisms. Animals and plants also produce AMPs to control their associated microbiota. In turn, defence mechanisms have evolved to prevent the action of these compounds. The close association of some Firmicutes with humans as prominent pathogens or commensal organisms has driven a considerable research effort on defence mechanisms used by these bacteria against antimicrobial compounds. This review focuses on the most recent advances on two well-characterized defence mechanisms against AMPs: the modification of the cell wall by D-alanylation and the role of peptide antibiotic-specific adenosine triphosphate-binding cassette transporters.
影响因子：
7.2
作者：
Silhavy, Thomas J.;Kahne, Daniel;Walker, Suzanne
通讯作者：
Walker, Suzanne
影响因子：
3.2
作者：
Kallenberg, Felix;Dintner, Sebastian;Gebhard, Susanne
通讯作者：
Gebhard, Susanne
影响因子：
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作者：
Fang, X;Tiyanont, K;Walker, S
通讯作者：
Walker, S