Myocardial function in rat genetic models of low and high aerobic running capacity.
Myocardial function in rat genetic models of low and high aerobic running capacity.
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低和高有氧跑步能力的大鼠遗传模型中的心肌功能。
DOI：
10.1152/ajpregu.00367.2001
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Cicila,GeorgeT
中科院分区：
文献类型：
--
作者：
Barbato,JohnC;Lee,SoonJin;Koch,LaurenGerard;Cicila,GeorgeT
We recently evaluated treadmill aerobic running capacity in 11 inbred strains of rats and found that isolated working left ventricular function correlated (r= 0.86) with aerobic running capacity. Among these 11 strains the Buffalo (BUF) hearts produced the lowest and the DA hearts the highest isolated cardiac output. The goal of this study was to investigate the components of cardiac function (i.e., coronary flow, heart rates, stroke volume, contractile dynamics, and cross-bridge cycling) to characterize further the BUF and DA inbred strains as potential models of contrasting myocardial performance. Cardiac performance was assessed using the Langendorff-Neely working heart preparation. Isolated DA hearts were superior (P< 0.05) to the BUF hearts for cardiac output (63%), stroke volume (60%), aortic +dP/dt(47%), and aortic −dP/dt(46%). The mean α/β-myosin heavy chain (MHC) isoform ratio for DA hearts was 21-fold higher relative to BUF hearts. At the steady-state mRNA level, DA hearts had a fivefold higher α/β-ratio than the BUF hearts. The mean rate of ATP hydrolysis by MHCs was 64% greater in DA compared with BUF ventricles. These data demonstrate that the BUF and DA strains can serve as genetic models of contrasting low and high cardiac function.
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DOI：
--
发表时间：
1949
期刊：
Medical world
影响因子：
--
作者：
T. Howell
通讯作者：
T. Howell
金属氟化物复合物抑制肌球蛋白 ATP 酶。
DOI：
10.1016/s0167-4838(98)00262-3
发表时间：
1999
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Park,S;Ajtai,K;Burghardt,TP
通讯作者：
Burghardt,TP
大鼠α心肌肌球蛋白重链基因表达的转录后调节。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Sindhwani,R;Ismail-Beigi,F;Leinwand,LA
通讯作者：
Leinwand,LA
接受或不接受硝苯地平治疗的大鼠心脏对慢性高血压的适应与年龄相关的差异
影响因子：
4.3
作者：
V. Raizada;D. Pathak;B. Skipper;A. Nakouzi;A. Malhotra
通讯作者：
A. Malhotra
关于最大摄氧量限制的新想法。
影响因子：
5.7
作者：
P. Wagner
通讯作者：
P. Wagner