Age-related difference in cardiac adaptation to chronic hypertension in rats, with and without nifedipine treatement
Age-related difference in cardiac adaptation to chronic hypertension in rats, with and without nifedipine treatement
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接受或不接受硝苯地平治疗的大鼠心脏对慢性高血压的适应与年龄相关的差异
DOI：
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发表时间：
1999
影响因子：
4.3
通讯作者：
A. Malhotra
中科院分区：
文献类型：
--
作者：
V. Raizada;D. Pathak;B. Skipper;A. Nakouzi;A. Malhotra
Three myosin isozymes, V1 (αα MHC = Myosin Heavy Chain gene), V2 (αβ MHC) and V3 (ββ MHC) that are identified in the cardiac ventricles of most mammals have been shown to shift to a V3 predominance pattern during cardiac growth and in response to left ventricular pressure overload, and to V1 predominance following anti hypertensive treatment. This study examined whether long-term hypertension impairs the ability of the adult heart to restructure myosin isozyme proportions. Using pyrophosphate gel electrophoresis, we studied proportions of cardiac myosin isozymes (V1 and V3) in young (16 weeks) and adult (36 weeks) spontaneously hypertensive rats (SHR), and following 12 weeks of nifedipine (N) treatment in age-matched SHR rats (SHR-N). The values of V1 and V3 myosin isozymes were derived by adding half of the value of V2 to each isozyme proportion. The V3 proportion in the young SHR control (SHR-C) group (49%) was 34% higher (p < 0.05) than in the young Wistar Kyoto control (WKY-C) group (37%). However, the proportion was similarly high, though not statistically significant, in both the adult SHRC (73%) and WKY-C (71%) groups. The proportion in the young SHR-N group (29%) was 41% lower (p < 0.05) than in the young SHR-C group (49%), and the proportion in the adult SHR-N group (47%) was 34% lower (p < 0.05) than in the adult SHR-C group (73%). The ratio of left ventricular weight to body weight (LVW/BW), which determines left ventricular hypertrophy (LVH), was higher in both young and adult SHR-C (26%, p < 0.05, and 42%, p < 0.05, respectively) than in WKY-C groups. The mean LVW/BW was 27% (p lt; 0.05) greater in adult than in young SHR-C rats. The LVW/BW in both age groups of treated SHR-N was similar to that in age matched WKY-C rats. Conclusion: Our study showed that a rise in the V3 level occurs in young hypertensive rats, but no rise occurs in the V3 level in adult hypertensive rats. High blood pressure seems to contribute to the high V3 level in young hypertensive rats, but in adult hypertensive rats, high blood pressure does not accentuate the V3 rise already acquired due to the aging process. Nifedipine treatment in both young and adult hypertensive rats prevented the V3 rise due to hypertension and to the aging process. This effect of nifedipine seems to be through its antihypertensive action.
心脏蛋白质周转率与年龄相关的变化。
影响因子：
5
作者：
Crie,JS;Millward,DJ;Bates,PC;Griffin,EE;Wildenthal,K
通讯作者：
Wildenthal,K
影响因子：
18.2
作者：
H. E. Morgan;E. E. Gordon-E.;Y. Kira;B H L Chua;L A Russo;C. J. Peterson;P J McDermott;P A Watson
通讯作者：
H. E. Morgan;E. E. Gordon-E.;Y. Kira;B H L Chua;L A Russo;C. J. Peterson;P J McDermott;P A Watson