Biomimetic nanoprobe-augmented triple therapy with photothermal, sonodynamic and checkpoint blockade inhibits tumor growth and metastasis.
Biomimetic nanoprobe-augmented triple therapy with photothermal, sonodynamic and checkpoint blockade inhibits tumor growth and metastasis.
复制标题
DOI：
10.1186/s12951-022-01287-y
复制
发表时间：
2022-02-15
影响因子：
10.2
通讯作者：
Li P
中科院分区：
文献类型：
--
作者：
Lin X;He T;Tang R;Li Q;Wu N;Zhou Y;He H;Wan L;Huang J;Jiang Q;Zhong Y;Xie Z;Hu Z;Zhou Y;Li P
多模式综合抗肿瘤治疗以其高效、抑制肿瘤转移等优点日益受到关注。我们描述了一种协同三联方案，结合光热和声动力学治疗（PTT和SDT），以及免疫检查点阻断，用于抑制4 T1小鼠模型中乳腺癌的生长和转移。PTT和SDT是协同增强的一种新型的多模式成像纳米探针集成与癌细胞膜仿生纳米粒子（CNOPs）负载超顺磁性氧化铁（SPIO）和血卟啉单甲醚（HMME）。BMPs表现出优异的同源肿瘤靶向，并且在磁共振、光声和光热成像的引导下由超声和近红外（NIR）光依次触发，导致完全原位肿瘤根除和全身抗肿瘤免疫激活。这种方法与免疫检查点阻断疗法的进一步组合显示出抑制肿瘤转移。这项工作提供了使用基于仿生纳米探针的多模式成像引导的PTT/SDT与免疫疗法相结合来消除肿瘤的三联疗法的原理证明。在线版本包含补充材料，可通过10.1186/s12951-022-01287-y获得。
Comprehensive antitumor therapy through integrated multimodal means has drawn increasing attention owing to its high efficiency and metastasis suppression. We describe a synergistic triple protocol combining photothermal and sonodynamic therapy (PTT and SDT), together with immune checkpoint blockade for the inhibition of breast cancer growth and metastases in the 4T1 mouse model. PTT and SDT are synergistically augmented by a novel multimodal imaging nanoprobe integrated with cancer cell membrane-biomimetic nanoparticles (CHINPs) loaded with superparamagnetic iron oxide (SPIO) and hematoporphyrin monomethyl ether (HMME). CHINPs exhibit excellent homologous tumor targeting, and are sequentially triggered by ultrasound and near infrared (NIR) light under the guidance of magnetic resonance, photoacoustic and photothermal imaging, leading to complete in situ tumor eradication and systemic anti-tumor immune activation. Further combination of this approach with immune checkpoint blockade therapy is shown to suppress tumor metastasis. This work provides proof-of-principle for triple therapy using multimodal imaging-guided PTT/SDT based on biomimetic nanoprobes in combination with immunotherapy to eliminate tumors. The online version contains supplementary material available at 10.1186/s12951-022-01287-y.
登录
查看更多内容
影响因子：
17.1
作者：
Cheng, Kai;Sano, Michael;Xing, Lei
通讯作者：
Xing, Lei
一种高单线态氧产生量的石墨烯量子点光动力治疗剂
影响因子：
16.6
作者：
Ge, Jiechao;Lan, Minhuan;Zhou, Bingjiang;Liu, Weimin;Guo, Liang;Wang, Hui;Jia, Qingyan;Niu, Guangle;Huang, Xing;Zhou, Hangyue;Meng, Xiangmin;Wang, Pengfei;Lee, Chun-Sing;Zhang, Wenjun;Han, Xiaodong
通讯作者：
Han, Xiaodong
影响因子：
16.6
作者：
He C;Duan X;Guo N;Chan C;Poon C;Weichselbaum RR;Lin W
通讯作者：
Lin W
二元协同前药纳米颗粒通过协同调节免疫肿瘤微环境改善免疫治疗
影响因子：
29.4
作者：
Feng, Bing;Zhou, Fangyuan;Li, Yaping
通讯作者：
Li, Yaping
DOI：
10.1073/pnas.1106634108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Hu, Che-Ming J.;Zhang, Li;Zhang, Liangfang
通讯作者：
Zhang, Liangfang