Campylobacter jejuni lipopolysaccharides in Guillain-Barré syndrome
Campylobacter jejuni lipopolysaccharides in Guillain-Barré syndrome
复制标题
吉兰-巴利综合征中的空肠弯曲菌脂多糖
作者：
K. Sheikh;I. Nachamkin;T. Ho;H. Willison;J. Veitch;H. Ung;M. Nicholson;C. Y. Li;H. S. Wu;B. Shen;D. Cornblath;A. Asbury;G. Mckhann;J. Griffin
目的：本研究旨在确定弯曲杆菌脂多糖（lps）中特定神经节苷类成分的存在是否与吉兰-巴罗综合征（GBS）的发生有关，并发现这些成分（包括GM1）在这些lps中出现的频率。方法：对7例GBS患者（5例急性运动轴索神经病变、1例急性炎性脱髓鞘多神经病变和1例Fisher综合征）的弯曲杆菌分离物和血清进行研究，并与单纯弯曲杆菌肠炎患者的类似标本进行比较。结果：所有GBS患者均有抗神经节苷脂抗体。与正常对照组或无并发症弯曲杆菌腹泻患者相比，弯曲杆菌感染后GBS患者的抗gm1和抗gd1a滴度均显著升高，包括轴突和脱髓鞘。从GBS患者和单独的肠炎患者分离的弯曲杆菌具有相似的神经节苷类部分。结论：这些结果表明，与非GBS腹泻患者相比，GBS患者对弯曲杆菌上神经节苷样表位的反应不同。我们的研究结果支持宿主易感性作为弯曲杆菌感染后结果的决定因素的作用。这些发现对研制空肠弯曲杆菌疫苗具有重要意义。
Objective: This study was designed to determine if the presence of specific ganglioside-like moieties in Campylobacter lipopolysaccharides(LPSs) is related to the development of Guillain-Barré syndrome (GBS), and to discover how frequently such moieties, including GM1, are present in these LPSs. Methods: We studied Campylobacter isolates and sera from seven patients with GBS (five acute motor axonal neuropathy, one acute inflammatory demyelinating polyneuropathy, and one Fisher's syndrome), and compared them with similar specimens from patients with Campylobacter enteritis alone. Results: All GBS patients had antiganglioside antibodies. Anti-GM1 and anti-GD1a titers were significantly elevated in post-Campylobacter GBS, both axonal and demyelinating, compared with normal control subjects or those with uncomplicated Campylobacter diarrhea. Campylobacter isolated from patients with GBS and with enteritis alone had similar ganglioside-like moieties. Conclusions: These results indicate that patients who develop GBS respond differently to the ganglioside-like epitopes on Campylobacter than do non-GBS diarrhea patients. Our findings support a role for host susceptibility as a determinant for the outcome following Campylobacter infection. These findings have important implications for the development of vaccines against Campylobacter jejuni.
影响因子：
14.5
作者：
HO, TW;MISHU, B;MCKHANN, GM
通讯作者：
MCKHANN, GM
接触实验感染的猪后，猪流感病毒会传播给人类。
DOI：
10.1093/infdis/175.1.7
发表时间：
1997
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Wentworth,DE;McGregor,MW;Macklin,MD;Neumann,V;Hinshaw,VS
通讯作者：
Hinshaw,VS