Brain repair after stroke--a novel neurological model.
Brain repair after stroke--a novel neurological model.
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DOI：
10.1038/nrneurol.2013.222
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Solodkin A
中科院分区：
文献类型：
--
作者：
Small SL;Buccino G;Solodkin A
中风后，患者通常会遗留严重的运动和言语障碍。本文综述了中风神经修复的最新进展，并提出了一个未来的新模式。我们认为，中风治疗——从发病之时到承受其后果——必须从根本上基于神经学原理，从一开始限制损伤程度，到修复后续损伤。我们的模式通过针对脑回路将大脑和行为联系起来，并且我们通过动作观察疗法来说明该模式，这种疗法旨在增强脑网络的连通性。该模式基于以下假设：神经修复机制本身涉及细胞和回路的可塑性，大脑可塑性是一种在很大程度上依赖刺激的突触现象，并且大脑修复需要针对特定脑回路重组的生理和行为干预措施。我们综述了目前中风后大脑修复的方法，提出了我们的新模式，并讨论了支持我们这种上肢和语言康复新方法的生物学基础、原理和数据。我们相信，通过在脑网络相互作用层面增强可塑性，这种用于大脑修复的神经学模式最终可能会治愈中风。
Following stroke, patients are commonly left with debilitating motor and speech impairments. This article reviews the state of the art in neurological repair for stroke and proposes a new model for the future. We suggest that stroke treatment—from the time of the ictus itself to living with the consequences—must be fundamentally neurological, from limiting the extent of injury at the outset, to repairing the consequent damage. Our model links brain and behaviour by targeting brain circuits, and we illustrate the model though action observation treatment, which aims to enhance brain network connectivity. The model is based on the assumptions that the mechanisms of neural repair inherently involve cellular and circuit plasticity, that brain plasticity is a synaptic phenomenon that is largely stimulus-dependent, and that brain repair required both physical and behavioural interventions that are tailored to reorganize specific brain circuits. We review current approaches to brain repair after stroke and present our new model, and discuss the biological foundations, rationales, and data to support our novel approach to upper-extremity and language rehabilitation. We believe that by enhancing plasticity at the level of brain network interactions, this neurological model for brain repair could ultimately lead to a cure for stroke.
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影响因子：
8.3
作者：
Cramer, SC;Nelles, G;Rosen, BR
通讯作者：
Rosen, BR
学习而不是适应性的是中风运动恢复的特征：在同一工作空间中，机器人辅助治疗在训练有素和未经训练的任务中引起的运动学变化的证据。
DOI：
10.1109/tnsre.2011.2175008
发表时间：
2012-01
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Dipietro L;Krebs HI;Volpe BT;Stein J;Bever C;Mernoff ST;Fasoli SE;Hogan N
通讯作者：
Hogan N
影响因子：
16.2
作者：
Buccino, G;Vogt, S;Rizzolatti, G
通讯作者：
Rizzolatti, G
DOI：
10.1044/jshd.4701.93
发表时间：
1982-01-01
期刊：
JOURNAL OF SPEECH AND HEARING DISORDERS
影响因子：
--
作者：
ATEN, JL;CALIGIURI, MP;HOLLAND, AL
通讯作者：
HOLLAND, AL
DOI：
10.1523/jneurosci.2851-12.2013
发表时间：
2013-03-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dick AS;Raja Beharelle A;Solodkin A;Small SL
通讯作者：
Small SL