Latent Class Analysis of Syndemic Factors Associated with Sustained Viral Suppression among Ryan White HIV/AIDS Program Clients in Miami, 2017.
Latent Class Analysis of Syndemic Factors Associated with Sustained Viral Suppression among Ryan White HIV/AIDS Program Clients in Miami, 2017.
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DOI：
10.1007/s10461-020-03153-0
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发表时间：
2021-07
影响因子：
4.4
通讯作者：
Sheehan DM
中科院分区：
文献类型：
--
作者：
Dawit R;Trepka MJ;Gbadamosi SO;Fernandez SB;Caleb-Adepoju SO;Brock P;Ladner RA;Sheehan DM
该研究的目的是确定持续的病毒抑制（所有病毒载量测试每年<200拷贝/毫升）与共同发生的风险因素模式之间的关联，这些风险因素包括艾滋病毒感染者（PWH）的精神健康、物质使用、性风险行为和不利的社会条件。对2017年迈阿密-戴德县瑞安·怀特项目6554名PWH进行潜在类分析并进行多变量logistic回归，选择五类模型。与1类（无危险因素）相比，2类（精神健康）（aOR: 0.67; 95% CI: 0.54-0.83）、3类（物质使用和多个性伴侣）（aOR: 0.60; 0.47-0.76）、4类（物质使用、多个性伴侣和家庭暴力）（0.71;0.55-0.93）和5类（精神健康、物质使用、多个性伴侣、家庭暴力和无家可归）（0.26;0.19-0.35）实现持续病毒抑制的几率显著降低。研究结果表明，需要针对这些综合征因素采取有针对性的干预措施。
The study’s objective was to identify the association between sustained viral suppression (all viral load tests <200 copies/ml per year) and patterns of co-occurring risk factors including, mental health, substance use, sexual risk behavior, and adverse social conditions for people with HIV (PWH). Latent class analysis followed by multivariable logistic regression was conducted for 6,554 PWH in the Miami-Dade County Ryan White Program during 2017, and a five-class model was selected. Compared to Class 1 (no risk factors), the odds of achieving sustained viral suppression was significantly lower for Class 2 (mental health) (aOR: 0.67; 95% CI: 0.54–0.83), Class 3 (substance use and multiple sexual partners) (0.60; 0.47–0.76), Class 4 (substance use, multiple sexual partners, and domestic violence) (0.71; 0.55–0.93), and Class 5 (mental health, substance use, multiple sexual partners, domestic violence, and homelessness) (0.26; 0.19–0.35). Findings indicate the need for targeted interventions that address these syndemic factors.
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DOI：
10.1016/j.socscimed.2006.05.012
发表时间：
2006-10
期刊：
Social science & medicine (1982)
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DOI：
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发表时间：
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