Plasma phospholipid transfer protein activity is inversely associated with betaine in diabetic and non-diabetic subjects.
Plasma phospholipid transfer protein activity is inversely associated with betaine in diabetic and non-diabetic subjects.
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DOI：
10.1186/s12944-016-0313-5
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发表时间：
2016-08-31
影响因子：
4.5
通讯作者：
Connelly MA
中科院分区：
文献类型：
--
作者：
Dullaart RP;Garcia E;Jeyarajah E;Gruppen EG;Connelly MA
胆碱代谢产物甜菜碱在脂类代谢中起作用，可预测心血管疾病和2型糖尿病的发生。磷脂转移蛋白(PLTP)和卵磷脂：胆固醇酰基转移酶(LCAT)需要以磷脂酰胆碱为底物，这增加了这些蛋白因子与胆碱代谢存在复杂关系的可能性。在此，我们确定了伴有和不伴有T2 DM的受试者PLTP和LCAT活性与甜菜碱的关系。本文测定了65例2型糖尿病(T2 DM)患者和55例非糖尿病患者的血浆甜菜碱(核磁共振波谱)、PLTP活性(脂质体-囊泡高密度脂蛋白系统)、LCAT活性(外源性底物法)和载脂蛋白(Apo)。T2 DM组PLTP和LCAT活性升高(p <； 0.0 5)，而甜菜碱差异不显著。在年龄、性别和糖尿病状态控制的相关分析中，甜菜碱与甘油三酯呈负相关，与高密度脂蛋白胆固醇呈正相关(p <； 0.0 5至0.0 1)。PLTP和LCAT活性与甘油三酯呈正相关，与高密度脂蛋白胆固醇呈负相关(p <； 0.05~0.001)。PLTP(r = −0.245，p = 0.006)和LCAT活性(r = −0.195，p = 0.035)与甜菜碱呈负相关。在对体重指数和脂蛋白变量进行额外调整后，PLTP活性与甜菜碱的负关联仍然显著(β = −0.179，p = 0.034)，而它与LCAT活性的关联失去了显著意义(β = −0.056，p = 0.44)。甜菜碱可能通过影响PLTP活性而影响脂蛋白代谢。
The choline metabolite, betaine, plays a role in lipid metabolism, and may predict the development of cardiovascular disease and type 2 diabetes mellitus (T2DM). Phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) require phosphatidylcholine as substrate, raising the possibility that there is an intricate relationship of these protein factors with choline metabolism. Here we determined the relationships of PLTP and LCAT activity with betaine in subjects with and without T2DM. Plasma betaine (nuclear magnetic resonance spectroscopy), PLTP activity (liposome-vesicle HDL system), LCAT activity (exogenous substrate assay) and (apo)lipoproteins were measured in 65 type 2 diabetic (T2DM) and in 55 non-diabetic subjects. PLTP and LCAT activity were elevated in T2DM (p < 0.05), whereas the difference in betaine was not significant. In age-, sex- and diabetes status-controlled correlation analysis, betaine was inversely correlated with triglycerides and positively with HDL cholesterol (p < 0.05 to 0.01). PLTP and LCAT activity were positively correlated with triglycerides and inversely with HDL cholesterol (p < 0.05 to 0.001). PLTP (r = −0.245, p = 0.006) and LCAT activity (r = −0.195, p = 0.035) were correlated inversely with betaine. The inverse association of PLTP activity with betaine remained significant after additional adjustment for body mass index and lipoprotein variables (β = −0.179, p = 0.034), whereas its association with LCAT activity lost significance (β = −0.056, p = 0.44). Betaine may influence lipoprotein metabolism via an effect on PLTP activity.
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影响因子：
3.7
作者：
Lever M;George PM;Slow S;Bellamy D;Young JM;Ho M;McEntyre CJ;Elmslie JL;Atkinson W;Molyneux SL;Troughton RW;Frampton CM;Richards AM;Chambers ST
通讯作者：
Chambers ST
影响因子：
11.1
作者：
Dullaart, R. P. F.;Vergeer, M.;Dallinga-Thie, G. M.
通讯作者：
Dallinga-Thie, G. M.
影响因子：
7.7
作者：
Walford GA;Ma Y;Clish C;Florez JC;Wang TJ;Gerszten RE;Diabetes Prevention Program Research Group
通讯作者：
Diabetes Prevention Program Research Group
影响因子：
39.3
作者：
Wang, Zeneng;Tang, W. H. Wilson;Hazen, Stanley L.
通讯作者：
Hazen, Stanley L.
影响因子：
3.7
作者：
Lever M;George PM;Atkinson W;Molyneux SL;Elmslie JL;Slow S;Richards AM;Chambers ST
通讯作者：
Chambers ST