Plasma lipids and betaine are related in an acute coronary syndrome cohort.
Plasma lipids and betaine are related in an acute coronary syndrome cohort.
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DOI：
10.1371/journal.pone.0021666
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Chambers ST
中科院分区：
文献类型：
--
作者：
Lever M;George PM;Atkinson W;Molyneux SL;Elmslie JL;Slow S;Richards AM;Chambers ST
低血浆甜菜碱与不利的血脂和心血管风险有关。在一些研究中，补充甜菜碱后血浆中甜菜碱升高与血脂升高有关。我们的目的是测量血浆和尿甜菜碱与血脂之间的关系，以及降脂药物对它们的影响。在急性冠状动脉综合征住院4个月后，收集531名受试者的空腹血浆样本（415名受试者的尿液样本）。在这项横断面研究中，比较了血浆甜菜碱和二甲基甘氨酸浓度和尿排泄与血浆脂质浓度。对性别、有无糖尿病、药物治疗进行亚组比较。血浆甜菜碱与甘油三酯（Spearman’s rs = - 0.22, p<0.0001）和非高密度脂蛋白胆固醇（rs = - 0.27, p<0.0001）呈负相关。血浆甜菜碱是BMI （p<0.05）和血浆非高密度脂蛋白胆固醇和甘油三酯（p<0.001）的预测因子，与性别、年龄和是否患有糖尿病无关。根据血浆甜菜碱十分位数分组的数据，血浆甜菜碱的增加与BMI （p = 0.008）和血浆非高密度脂蛋白胆固醇（p = 0.002）的降低呈线性相关。在非线性关系中，甜菜碱与血浆甘油三酯升高呈负相关（p = 0.004），仅当血浆甜菜碱浓度为45µmol/L时。服用他汀类药物的受试者血浆中甜菜碱浓度较高（p<0.001）。接受贝特治疗的受试者血浆甜菜碱降低（p = 0.003），可能是由于尿中甜菜碱流失升高（p<0.001）。血浆甜菜碱较高的受试者和服用他汀类药物的受试者的辅酶Q与非高密度脂蛋白胆固醇的比值较高。低血浆甜菜碱浓度与不利的血脂相关。甜菜碱缺乏症在研究人群中可能很常见。应在适当人群中进行甜菜碱补充的对照临床试验，以确定纠正是否会影响心血管风险。
Low plasma betaine has been associated with unfavorable plasma lipid profiles and cardiovascular risk. In some studies raised plasma betaine after supplementation is associated with elevations in plasma lipids. We aimed to measure the relationships between plasma and urine betaine and plasma lipids, and the effects of lipid-lowering drugs on these. Fasting plasma samples were collected from 531 subjects (and urine samples from 415) 4 months after hospitalization for an acute coronary syndrome episode. In this cross-sectional study, plasma betaine and dimethylglycine concentrations and urine excretions were compared with plasma lipid concentrations. Subgroup comparisons were made for gender, with and without diabetes mellitus, and for drug treatment. Plasma betaine negatively correlated with triglyceride (Spearman's rs = −0.22, p<0.0001) and non-high-density lipoprotein cholesterol (rs = −0.27, p<0.0001). Plasma betaine was a predictor of BMI (p<0.05) and plasma non-high-density lipoprotein cholesterol and triglyceride (p<0.001) independently of gender, age and the presence of diabetes. Using data grouped by plasma betaine decile, increasing plasma betaine was linearly related to decreases in BMI (p = 0.008) and plasma non-HDL cholesterol (p = 0.002). In a non-linear relationship betaine was negatively associated with elevated plasma triglycerides (p = 0.004) only for plasma betaine >45 µmol/L. Subjects taking statins had higher plasma betaine concentrations (p<0.001). Subjects treated with a fibrate had lower plasma betaine (p = 0.003) possibly caused by elevated urine betaine loss (p<0.001). The ratio of coenzyme Q to non-high-density lipoprotein cholesterol was higher in subjects with higher plasma betaine, and in subjects taking a statin. Low plasma betaine concentrations correlated with an unfavourable lipid profile. Betaine deficiency may be common in the study population. Controlled clinical trials of betaine supplementation should be conducted in appropriate populations to determine whether correction affects cardiovascular risk.
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