Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation.
Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation.
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DOI：
10.1016/j.devcel.2011.07.005
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发表时间：
2011-09-13
影响因子：
11.8
通讯作者：
Angela Nieto, M.
中科院分区：
文献类型：
--
作者：
Acloque, Herve;Ocana, Oscar H.;Matheu, Ander;Rizzoti, Karine;Wise, Clare;Lovell-Badge, Robin;Angela Nieto, M.
在发育中的胚胎中，第一次上皮-间充质转化（EMT）发生在原肠胚形成时，当上胚层细胞的子集移动到原条并经历EMT以内化并产生中胚层和内胚层时。我们表明，在鸡胚中，这种内化决定是由Snail 2和Sox 3因子的相互转录抑制介导的。我们还表明，Sox 3和Snail之间的关系在小鼠胚胎和人类癌细胞中是保守的。在胚胎中，表达Snail的细胞在原条处进入，而Sox 3阳性细胞不能进入，确保外胚层衍生物的形成。因此，早期胚胎分为两个主要领域，外胚层和中内胚层，是由Sox 3和蜗牛转录因子之间的拮抗关系介导的细胞行为的变化来调节。Snail和Sox 3是相互的直接转录抑制因子Snail/Sox 3相互抑制定义了外胚层与中内胚层的区域Snail 2诱导细胞分层而不诱导中胚层或内胚层的命运Snail/Sox 3关系在小鼠胚胎和人类癌细胞中是保守的
In developing amniote embryos, the first epithelial-to-mesenchymal transition (EMT) occurs at gastrulation, when a subset of epiblast cells moves to the primitive streak and undergoes EMT to internalize and generate the mesoderm and the endoderm. We show that in the chick embryo this decision to internalize is mediated by reciprocal transcriptional repression of Snail2 and Sox3 factors. We also show that the relationship between Sox3 and Snail is conserved in the mouse embryo and in human cancer cells. In the embryo, Snail-expressing cells ingress at the primitive streak, whereas Sox3-positive cells, which are unable to ingress, ensure the formation of ectodermal derivatives. Thus, the subdivision of the early embryo into the two main territories, ectodermal and mesendodermal, is regulated by changes in cell behavior mediated by the antagonistic relationship between Sox3 and Snail transcription factors. ► Snail and Sox3 are reciprocal direct transcriptional repressors ► Snail/Sox3 reciprocal repression defines ectodermal versus mesendodermal territories ► Snail2 induces cell delamination without inducing mesodermal or endodermal fates ► The Snail/Sox3 relationship is conserved in mouse embryos and human cancer cells
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影响因子：
5.3
作者：
KELLER, G;KENNEDY, M;WILES, MV
通讯作者：
WILES, MV
影响因子：
64.8
作者：
Brennan, J;Lu, CC;Robertson, EJ
通讯作者：
Robertson, EJ
DOI：
10.1007/bf00309751
发表时间：
1987-01-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
FLAMME, I
通讯作者：
FLAMME, I
影响因子：
5.3
作者：
Carver, EA;Jiang, RL;Gridley, T
通讯作者：
Gridley, T
影响因子：
--
作者：
Chapman SC;Matsumoto K;Cai Q;Schoenwolf GC
通讯作者：
Schoenwolf GC