Effects of Amino Acid Infusion on Renal Hemodynamics: Role of Endothelium‐Derived Relaxing Factor
Effects of Amino Acid Infusion on Renal Hemodynamics: Role of Endothelium‐Derived Relaxing Factor
复制标题
氨基酸输注对肾血流动力学的影响：内皮衍生舒张因子的作用
作者：
J. P. Tolins;L. Raij
摄入蛋白质或静脉输注氨基酸会以未知的机制急剧提高肾小球滤过率（GFR）和肾血浆流量（RPF）。内皮源性舒张因子（EDRF）参与血管张力的局部调节，目前已知是由l -精氨酸代谢产生的一氧化氮。为了探讨氨基酸输注后EDRF可能参与肾脏血管扩张和GFR升高的假设，我们观察了ng -单甲基l -精氨酸（LNMMA）抑制EDRF合成对大鼠肾脏基础血流动力学的影响以及10%混合氨基酸溶液（1ml /hr静脉滴注）输注后大鼠的反应。肾动脉输注LNMMA （500/μ/kg/min）导致平均动脉压显著升高，GFR（20%）和RPF（44%）降低，滤过率显著升高。用angjotensin II受体拮抗剂Sar-Gly-angiotensin II进行预处理不能防止血压升高，但可以减弱LNMMA输注后GFR（11%）和RPF（27%）的下降。氨基酸输注未处理的空腹大鼠血压无变化，但GFR和RPF显著升高；这些作用被肾内LNMMA完全抑制，而非等压静脉输注苯肾上腺素。综上所述，EDRF参与了基础肾血流动力学的调节。此外，氨基酸诱导的高滤过和肾血管舒张被抑制EDRF合成完全阻止。我们认为EDRF可能参与了氨基酸输注后肾脏血流动力学的反应。
Ingestion of protein or intravenous infusion of amino acids acutely elevates glomerular filtration rate (GFR) and renal plasma flow (RPF) by unknown mechanisms. Endotheliumderived relaxing factor (EDRF), now known to be nitric oxide derived from metabolism L-arginine, participates in local regulation of vascular tone. To investigate the hypothesis that EDRF may participate in the renal vasodilatation and increased GFR after amino acid infusion, we characterized the effect of inhibition of EDRF synthesis with NG-monomethyl L-arginine (LNMMA) on basal renal hemodynamics and the response to infusion of a 10% mixed amino acid solution (1 ml/hr i.v.) in the rat. Renal arterial infusion of LNMMA (500/μ/kg/min) resulted in a significant increase in mean arterial pressure, decreases in GFR (20%) and RPF (44%), and a significant increase in filtration fraction. Pretreatment with the angjotensin II receptor antagonist Sar-Gly-angiotensin II did not prevent the increase in blood pressure but blunted the decreases in GFR (11%) and RPF (27%) after LNMMA infusion. Amino acid infusion in the untreated, fasted rat resulted in no change in blood pressure but significant increases in GFR and RPF; these effects were completely inhibited by intrarenal LNMMA but not an equihypertensive intravenous infusion of phenylephrine. In summary, EDRF participates in regulation of basal renal hemodynamics. Furthermore, amino acidinduced hyperfiltration and renal vasodilatation are completely prevented by inhibition EDRF synthesis. We conclude that EDRF may participate in the renal hemodynamic response to amino acid infusion.
影响因子：
158.5
作者：
BRENNER, BM;MEYER, TW;HOSTETTER, TH
通讯作者：
HOSTETTER, TH
血管紧张素 II 和去甲肾上腺素对离体大鼠传入和传出小动脉的影响。
DOI：
10.1152/ajprenal.1990.258.3.f741
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Yuan,BH;Robinette,JB;Conger,JD
通讯作者：
Conger,JD
肾血流动力学的餐后调节：胰高血糖素的作用。
DOI：
10.1152/ajprenal.1985.248.5.f656
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Premen,AJ;Hall,JE;SmithJr,MJ
通讯作者：
SmithJr,MJ