Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus.

Unique transducins expressed in long and short photoreceptors of lamprey Petromyzon marinus.
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DOI:
10.1016/j.visres.2008.07.006
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发表时间:
2008-09
期刊:
影响因子:
1.8
通讯作者:
Artemyev, Nikolai O.
Artemyev, Nikolai O.
中科院分区:
心理学3区
文献类型:
--
作者:
Muradov, Hakim;Kerov, Vasily;Boyd, Kimberly K.;Artemyev, Nikolai O.

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七鳃鳗代表了最原始的无颌鱼类,并作为脊椎动物视觉系统的进化模型。为了解视杆细胞和视锥细胞感光细胞G蛋白的分子起源,对七鳃鳗Petromyzonmarinus的转导蛋白-α(Gαt)亚基进行了研究。在海对虾视网膜中鉴定出两个Gαt亚基GαtL和GαtS。GαtL与视锥和视杆G蛋白的距离相等,并且在七鳃鳗的长光感受器中表达。短的感光细胞GαtS是一种杆状的转导蛋白-α,它保留了锥细胞转导蛋白的一些独特特征。因此,祖先转导蛋白基因的复制产生杆转导蛋白已经发生在有颌和无颌脊椎动物的最后共同祖先。
Lampreys represent the most primitive vertebrate class of jawless fish and serve as an evolutionary model of the vertebrate visual system. Transducin-α (Gαt) subunits were investigated in lamprey Petromyzon marinus in order to understand the molecular origins of rod and cone photoreceptor G proteins. Two Gαt subunits, GαtL and GαtS, were identified in the P. marinus retina. GαtL is equally distant from cone and rod G proteins and is expressed in the lamprey’s long photoreceptors. The short photoreceptor GαtS is a rod-like transducin-α that retains several unique features of cone transducins. Thus, the duplication of the ancestral transducin gene giving rise to rod transducins has already occurred in the last common ancestor of the jawed and jawless vertebrates.
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