Effect of vitreous on morphologic characteristics of retinal pigment epithelial cells. A new approach to the study of proliferative vitreoretinopathy.
Effect of vitreous on morphologic characteristics of retinal pigment epithelial cells. A new approach to the study of proliferative vitreoretinopathy.
复制标题
玻璃体对视网膜色素上皮细胞形态特征的影响。
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
B. Glaser
中科院分区：
文献类型：
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作者：
J. Vidaurri;R. Hohman;B. Glaser
正常情况下，融合单层的人视网膜色素上皮（RPE）细胞保持六边形至椭圆形。然而，当这些单层与自体玻璃体覆盖时，RPE细胞伸长并作为双极纤维细胞样细胞迁移到玻璃体凝胶中。我们分别研究了透明质酸钠和胶原蛋白的作用。透明质酸覆盖的视网膜色素上皮细胞没有改变其形态特征。相比之下，当RPE单层与胶原凝胶覆盖时，细胞从其正常上皮特征变为后来迁移到胶原凝胶中的双极纤维细胞样细胞。RPE细胞暴露于玻璃体可能在增生性玻璃体视网膜病变的发病机制中起作用。
Normally, human retinal pigment epithelial (RPE) cells in confluent monolayers maintain a hexagonal to oval shape. However, when these monolayers were overlaid with autologous vitreous, the RPE cells elongated and migrated into the vitreous gel as bipolar fibrocytelike cells. We studied the effect of sodium hyaluronate and collagen individually. Retinal pigment epithelial cells overlaid with hyaluronate did not change their morphologic features. In contrast, when RPE monolayers were overlaid with a collagen gel, the cells changed from their normal epithelial characteristics to bipolar fibrocytelike cells that later migrated into the collagen gel. Exposure of RPE cells to vitreous may play a role in the pathogenesis of proliferative vitreoretinopathy.
影响因子：
4.2
作者：
N. Radtke;Yasuo Tano;David B. Chandler;R. Machemer
通讯作者：
N. Radtke;Yasuo Tano;David B. Chandler;R. Machemer