Amyloid PET imaging in Alzheimer's disease: a comparison of three radiotracers.
Amyloid PET imaging in Alzheimer's disease: a comparison of three radiotracers.
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DOI：
10.1007/s00259-014-2753-3
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发表时间：
2014-07
影响因子：
9.1
通讯作者：
Jagust, W. J.
中科院分区：
文献类型：
--
作者：
Landau, S. M.;Thomas, B. A.;Thurfjell, L.;Schmidt, M.;Margolin, R.;Mintun, M.;Pontecorvo, M.;Baker, S. L.;Jagust, W. J.
淀粉样蛋白PET在阿尔茨海默病研究和临床试验中的使用越来越多，促使人们努力使方法标准化。我们使用两个研究人群比较了11 C放射性示踪剂匹兹堡化合物B（Pi B）与两种18 F淀粉样蛋白放射性示踪剂（florbetapir和flutemetamine）的示踪剂保留。我们还研究了在示踪剂特异性测量之间转换的可行性，使用PiB作为两种18F示踪剂之间的共同联系。一组受试者（N=40）接受PiB和flutemetapir成像，另一组（N=32）接受PiB和florbetapir成像。我们比较了皮质和白色物质保留的每一个F18示踪剂相对于PiB，以及几个参考区域和图像分析方法。示踪剂对之间的关联用于在示踪剂特异性值之间转换淀粉样蛋白阳性的阈值。每对示踪剂的皮质保留强烈相关，与参考区域（氟美他莫-PiB，ρ=0.84-0.99;氟倍他匹-PiB，ρ=0.83-0.97）和分析方法（ρ=0.90-0.99）无关。与PiB相比，flutemetapir具有较高的白色物质保留，而florbetapir具有较低的皮质保留。两个先前建立的淀粉样蛋白阳性的独立阈值是高度一致的，当值之间的示踪剂对转换。尽管不同的白色和灰质保留的特点，皮质保留的每一个F18示踪剂是高度相关的PiB，使转换的阈值跨示踪剂测量尺度具有高水平的内部一致性。分析方法和测量尺度的标准化可能有助于比较使用不同示踪剂获得的淀粉样蛋白PET数据。
The increasing use of amyloid PET in Alzheimer’s disease research and clinical trials has motivated efforts to standardize methodology. We compared tracer retention for 11C radiotracer Pittsburgh Compound B (PiB) with two 18F amyloid radiotracers (florbetapir and flutemetamol) using two study populations. We also examined the feasibility of converting between tracer-specific measures, using PiB as the common link between the two 18F tracers. One group of subjects (N=40) underwent PiB and flutemetamol imaging sessions and a separate group (N=32) underwent PiB and florbetapir imaging sessions. We compared cortical and white matter retention for each F18 tracer relative to PiB, as well as several reference regions and image analysis methods. Associations between tracer pairs were used to convert thresholds for amyloid positivity between tracer-specific values. Cortical retention for each pair of tracers was strongly correlated regardless of reference region (flutemetamol-PiB, ρ=0.84–0.99; florbetapir-PiB, ρ=0.83–0.97) and analysis method (ρ=0.90–0.99). Compared to PiB, flutemetamol had higher white matter retention, while florbetapir had lower cortical retention. Two previously established independent thresholds for amyloid positivity were highly consistent when values were converted between tracer pairs. Despite differing white and grey matter retention characteristics, cortical retention for each F18 tracer was highly correlated with PiB, enabling conversion of thresholds across tracer measurement scales with a high level of internal consistency. Standardization of analysis methods and measurement scales may facilitate the comparison of amyloid PET data obtained using different tracers.
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影响因子：
11.2
作者：
Landau, Susan M.;Mintun, Mark A.;Joshi, Abhinay D.;Koeppe, Robert A.;Petersen, Ronald C.;Aisen, Paul S.;Weiner, Michael W.;Jagust, William J.
通讯作者：
Jagust, William J.
DOI：
10.1136/jnnp-2012-302548
发表时间：
2012-09
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Wolk DA;Zhang Z;Boudhar S;Clark CM;Pontecorvo MJ;Arnold SE
通讯作者：
Arnold SE
影响因子：
48
作者：
Rowe, Christopher C.;Ackerman, Uwe;Villemagne, Victor L.
通讯作者：
Villemagne, Victor L.
影响因子：
9.9
作者：
Jagust, W. J.;Landau, S. M.;Mathis, C. A.
通讯作者：
Mathis, C. A.
DOI：
10.1007/s00259-012-2088-x
发表时间：
2012-06-01
影响因子：
9.1
作者：
Villemagne, Victor L.;Mulligan, Rachel S.;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.