Breast lesions excised via vacuum-assisted system: could we get any clues for B3 lesions before excision biopsy?
Breast lesions excised via vacuum-assisted system: could we get any clues for B3 lesions before excision biopsy?
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真空辅助系统切除乳腺病灶：切除活检前能否获得B3病灶的线索？
DOI：
10.1186/s12885-021-08382-7
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发表时间：
2021-05-29
期刊：
影响因子：
3.8
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Zheng L;Zheng F;Xing Z;Zhang Y;Li Y;Xu H;Lai Y;Li J;Wang W
本研究的目的是确定超声特征的有效性，以及在真空辅助切除活检（VAEB）之前分配给B3（不确定的恶性潜能）乳房病变的患者特征。本研究人群包括2245名乳腺结节异常的女性，这些女性都进行了超声引导下的VAEB （US-VAEB）。以组织病理学结果为基准，将US-VAEB术前采集的患者临床、记忆资料及病变相关的B3超声特征变量与良、恶性病例进行比较。us - vaeb术后乳腺良、B3和恶性病变的诊断比例分别为88.5%、8.2和3.4%。B3高发生率分别为BI-RADS-US 3级（7.7%）、4a级（11.0%）和4b级（9.1%）。B3的总体恶性低估率为4.4%（8/183）。恶性病变多见于BI-RADS 4b级（27.3%）、4c级（33.3%）和5级（100%）。多变量二元logistic回归分析（B3 vs良性）显示，非绝经期患者（95% CI 1.628-8.616, P = 0.002）、超声特征中单一结节（95% CI 1.3.7 - 2.650, P = 0.000）或血管性结节（95% CI 1.75 - 4.150, P = 0.000）是发生B3的重要危险因素。此外，年龄大于50岁（95% CI 3.178 ~ 19.816, P = 0.000）、切缘不清（95% CI 3.571 ~ 14.119, P = 0.000）或可疑钙化（95% CI 4.010 ~ 30.733, P = 0.000）病变与B3病例（恶性vs B3）恶性潜在风险显著相关。本研究结果提示，超声表现和患者特征可能为VAEB前乳腺良性病变与B3病变的区分提供有价值的信息，有助于减少B3的恶性低估。
The purpose of this study was to determine the validity of the ultrasound features as well as patient characteristics assigned to B3 (uncertain malignant potential) breast lesions before vacuum-assisted excision biopsy (VAEB). This study population consisted of 2245 women with breast-nodular abnormalities, which were conducted ultrasound-guided VAEB (US-VAEB). Patient’s clinical and anamnestic data and lesion-related ultrasonic feature variables of B3 captured before US-VAEB were compared with those of benign or malignant cases, using histopathological results as a benchmark. The proportions of benign, B3 and malignant breast lesions diagnosed post-US-VAEB were 88.5, 8.2 and 3.4% respectively. B3 high frequent occurred in BI-RADS-US grade 3 (7.7%), grade 4a (11.0%) and grade 4b (9.1%). The overall malignancy underestimation rate of B3 was 4.4% (8/183). Malignant lesions were found mostly in the range of BI-RADS grade 4b (27.3%), grade 4c (33.3%) and grade 5 (100%). Multivariate binary logistic regression analyses (B3 vs benign) showed that non-menopausal patients (95% CI 1.628–8.616, P = 0.002), single (95% CI 1.370–2.650, P = 0.000) or vascularity (95% CI 1.745–4.150, P = 0.000) nodules in ultrasonic features were significant risk factors for B3 occurrences. In addition, patients elder than 50 years (95% CI 3.178–19.816, P = 0.000), unclear margin (95% CI 3.571–14.119, P = 0.000) or suspicious calcification (95% CI 4.010–30.733, P = 0.000) lesions were significantly associated with higher risks of malignant potentials for B3 cases (malignant vs B3). The results of this study indicate that ultrasound findings and patients’ characteristics might provide valuable information for distinguishing B3 lesions from benign breast abnormalities before VAEB, and help to reduce malignancy underestimation of B3.
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DOI：
10.5114/aoms.2014.40734
发表时间：
2014-02-24
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Chen M;Zhan WW;Wang WP
通讯作者：
Wang WP
影响因子：
16.2
作者：
Feng, Rui-Mei;Zong, Yi-Nan;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
1.3
作者：
Hodorowicz-Zaniewska, Diana;Siarkiewicz, Benita;Szpor, Joanna
通讯作者：
Szpor, Joanna
影响因子：
5.9
作者：
Londero, Viviana;Zuiani, Chiara;Bazzocchi, Massimo
通讯作者：
Bazzocchi, Massimo
影响因子：
2.6
作者：
Bennett, Ian;de Viana, Daniel;Saboo, Apoorva
通讯作者：
Saboo, Apoorva