MicroRNA-24 modulates aflatoxin B1-related hepatocellular carcinoma prognosis and tumorigenesis.
MicroRNA-24 modulates aflatoxin B1-related hepatocellular carcinoma prognosis and tumorigenesis.
复制标题
MicroRNA-24 调节黄曲霉毒素 B1 相关的肝细胞癌预后和肿瘤发生
DOI：
10.1155/2014/482926
复制
发表时间：
2014
影响因子：
--
通讯作者：
Xia Q
中科院分区：
文献类型：
--
作者：
Liu YX;Long XD;Xi ZF;Ma Y;Huang XY;Yao JG;Wang C;Xing TY;Xia Q
microRNA-24（miR-24）可能参与肿瘤的形成过程，但其在黄曲霉毒素B1（AFB 1）相关的肝细胞癌（HCC）中的作用尚不清楚。在这里，我们检测了207例病理诊断的HCC病例中miR-24的表达，这些病例来自高AFB 1暴露区域和HCC细胞。我们发现miR-24在HCC肿瘤组织中相对于邻近的非癌组织样本上调，并且miR-24的高表达与较大的肿瘤大小、较高的微血管密度和肿瘤去分化显著相关。此外，这种microRNA过表达改变了HCC患者的无复发生存率（相对风险比[HR]，4.75; 95%置信区间[CI]，2.66-8.47）和总生存率（HR = 3.58，95% CI = 2.34-5.46）。此外，我们观察到miR-24和AFB 1暴露对HCC预后的联合作用的一些证据。在功能上，miR-24过表达促进肿瘤细胞增殖，抑制细胞凋亡，并形成AFB 1-DNA加合物。这些结果首次表明，miR-24可能改变AFB 1相关的HCC预后和肿瘤发生。
MicroRNA-24 (miR-24) may be involved in neoplastic process; however, the role of this microRNA in the hepatocellular carcinoma (HCC) related to aflatoxin B1 (AFB1) has not been well elaborated. Here, we tested miR-24 expression in 207 pathology-diagnosed HCC cases from high AFB1 exposure areas and HCC cells. We found that miR-24 was upregulated in HCC tumor tissues relative to adjacent noncancerous tissue samples, and that the high expression of miR-24 was significantly correlated with larger tumor size, higher microvessel density, and tumor dedifferentiation. Additionally, this microRNA overexpression modified the recurrence-free survival (relative hazard ratio [HR], 4.75; 95% confidence interval [CI], 2.66–8.47) and overall survival (HR = 3.58, 95% CI = 2.34–5.46) of HCC patients. Furthermore, we observed some evidence of joint effects between miR-24 and AFB1 exposure on HCC prognosis. Functionally, miR-24 overexpression progressed tumor cells proliferation, inhibited cell apoptosis, and developed the formation of AFB1-DNA adducts. These results indicate for the first time that miR-24 may modify AFB1-related HCC prognosis and tumorigenesis.
登录
查看更多内容
影响因子：
64.5
作者：
Hatziapostolou M;Polytarchou C;Aggelidou E;Drakaki A;Poultsides GA;Jaeger SA;Ogata H;Karin M;Struhl K;Hadzopoulou-Cladaras M;Iliopoulos D
通讯作者：
Iliopoulos D
影响因子：
3.8
作者：
Kensler, Thomas W.;Roebuck, Bill D.;Groopman, John D.
通讯作者：
Groopman, John D.
影响因子：
14.9
作者：
Griffiths-Jones, S
通讯作者：
Griffiths-Jones, S
影响因子：
13.5
作者：
Rogler, Charles E.;LeVoci, Lauretta;Rogler, Leslie E.
通讯作者：
Rogler, Leslie E.
三氧化二砷处理 HepG-2 细胞后 microRNA 表达变化
DOI：
10.1111/j.1440-1746.2010.06317.x
发表时间：
2011-01-01
影响因子：
4.1
作者：
Meng, Xian-Zhi;Zheng, Tong-Sen;Liu, Lian-Xin
通讯作者：
Liu, Lian-Xin