The dynamics of the early inflammatory response in double-hit burn and sepsis animal models.
The dynamics of the early inflammatory response in double-hit burn and sepsis animal models.
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DOI：
10.1016/j.cyto.2011.07.001
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发表时间：
2011-11
期刊：
影响因子：
3.8
通讯作者：
Androulakis, Ioannis P.
中科院分区：
文献类型：
--
作者：
Orman, Mehmet A.;Ierapetritou, Marianthi G.;Berthiaume, Francois;Androulakis, Ioannis P.
严重烧伤通常与细菌感染有关，细菌感染会导致持续的高代谢和分解代谢状态的炎症反应。这种复杂的生物反应由趋化因子和细胞因子介导，当介质之间发生过度相互作用时，可能会更加严重。本研究通过检测23种不同的细胞因子和趋化因子，分析了盲肠结扎穿孔(CLP)或相应的对照治疗(假CLP或SCLP)对烧伤(B)雄性大鼠早期炎症反应的影响。B+CLP组和B+SCLP组细胞因子和趋化因子，包括单核细胞趋化蛋白-1、IP-10、瘦素、肿瘤坏死因子-α、巨噬细胞趋化因子-1α、IL-18、巨噬细胞集落刺激因子、RANTES和巨噬细胞集落刺激因子均有显著变化。与B+SCLP组相比，B+CLP组IL-10和IL-6表达显著上调。瘦素和IP-10浓度下调与手术和/或感染有关。IL-18和MCP-1在所有组均升高，包括先前发表的接受类似治疗的单发损伤模型。在这项研究中，在双重打击模型中，侮辱特异性调节因子及其特有的时间模式被阐明。
Severe burn trauma is generally associated with bacterial infections, which causes a more persistent inflammatory response with an ongoing hypermetabolic and catabolic state. This complex biological response, mediated by chemokines and cytokines, can be more severe when excessive interactions between the mediators take place. In this study, the early inflammatory response following the cecum ligation and puncture (CLP) or its corresponding control treatment (sham-CLP or SCLP) in burn (B) male rats was analyzed by measuring 23 different cytokines and chemokines. Cytokines and chemokines, including MCP-1, IP-10, Leptin, TNF-α, MIP-1α, IL-18, GMCSF, RANTES and GCSF were significantly altered in both B+CLP and B+SCLP groups. IL-10 and IL-6 were significantly up-regulated in the B+CLP group when compared to the B+SCLP group. Down regulation of Leptin and IP-10 concentrations were found to be related to surgery and/or infection. IL-18 and MCP-1 were elevated in all groups including previously published single injury models receiving similar treatments. In this study, insult-specific mediators with their characteristic temporal patterns were elucidated in double hit models.
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影响因子：
3.8
作者：
Banta, Scott;Vemula, Murali;Yarmush, Martin L.
通讯作者：
Yarmush, Martin L.
影响因子：
--
作者：
Bhatia, Madhav;Hegde, Akhil
通讯作者：
Hegde, Akhil
影响因子：
9
作者：
Göebel, A;Kavanagh, E;Rodrick, ML
通讯作者：
Rodrick, ML
DOI：
10.1097/01.bcr.0000150212.21651.79
发表时间：
2005-01-01
期刊：
JOURNAL OF BURN CARE & REHABILITATION
影响因子：
--
作者：
Gosain, A;Gamelli, RL
通讯作者：
Gamelli, RL
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y