Impact of the COVID-19 pandemic on in-hospital mortality in cardiovascular disease: a meta-analysis.
Impact of the COVID-19 pandemic on in-hospital mortality in cardiovascular disease: a meta-analysis.
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DOI：
10.1093/eurjpc/zwab119
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发表时间：
2022-05-27
影响因子：
8.3
通讯作者：
Bromage DI
中科院分区：
文献类型：
--
作者：
Cannata A;Watson SA;Daniel A;Giacca M;Shah AM;McDonagh TA;Scott PA;Bromage DI
COVID-19大流行导致COVID-19直接和其他疾病（包括心血管（CV）疾病）导致死亡率过高。我们旨在探索一系列CV疾病中与COVID-19感染无关的过度住院死亡率。对研究无SARS-CoV-2感染的心血管疾病住院患者与COVID-19大流行期以外时期相比的住院死亡率的研究进行了系统检索。分析中纳入了涉及27421例CV疾病患者的15项研究。COVID-19组的平均住院死亡率为10.4%（n = 974），对照组为5.7%（n = 1026）。与COVID-19大流行以外的时期相比，合并风险比（RR）显示COVID-19期间的住院死亡率增加了62%[95%置信区间（CI）1.20-2.20，P = 0.002]。在COVID-19大流行期间，入院率下降>50%的研究与下降<50%的研究相比，观察到死亡率增加最多[RR 2.74（95%CI 2.43-3.10）vs. 1.21（95%CI 1.07-1.37），P < 0.001]。观察到的死亡率增加在不同CV条件下一致（相互作用P = 0.74）。心血管疾病住院患者的住院死亡率相对于大流行以外的时期有所增加，与COVID-19合并感染无关。在入院率下降最大的研究中，这种影响更大，表明在此期间患者的病情更严重。然而，研究通常进行得很差，需要进一步精心设计的研究来确定与COVID-19感染无直接关系的死亡率的全部范围。
The COVID-19 pandemic has resulted in excess mortality due to both COVID-19 directly and other conditions, including cardiovascular (CV) disease. We aimed to explore the excess in-hospital mortality, unrelated to COVID-19 infection, across a range of CV diseases. A systematic search was performed for studies investigating in-hospital mortality among patients admitted with CV disease without SARS-CoV-2 infection compared with a period outside the COVID-19 pandemic. Fifteen studies on 27 421 patients with CV disease were included in the analysis. The average in-hospital mortality rate was 10.4% (n = 974) in the COVID-19 group and 5.7% (n = 1026) in the comparator group. Compared with periods outside the COVID-19 pandemic, the pooled risk ratio (RR) demonstrated increased in-hospital mortality by 62% during COVID-19 [95% confidence interval (CI) 1.20–2.20, P = 0.002]. Studies with a decline in admission rate >50% during the COVID-19 pandemic observed the greatest increase in mortality compared with those with <50% reduction [RR 2.74 (95% CI 2.43–3.10) vs. 1.21 (95% CI 1.07–1.37), P < 0.001]. The observed increased mortality was consistent across different CV conditions (P = 0.74 for interaction). In-hospital mortality among patients admitted with CV diseases was increased relative to periods outside the pandemic, independent of co-infection with COVID-19. This effect was larger in studies with the biggest decline in admission rates, suggesting a sicker cohort of patients in this period. However, studies were generally poorly conducted, and there is a need for further well-designed studies to establish the full extent of mortality not directly related to COVID-19 infection.
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Covid-19对急性心力衰竭住院住院的影响：英国西南部的单一中心经历。
影响因子：
3.8
作者：
Doolub G;Wong C;Hewitson L;Mohamed A;Todd F;Gogola L;Skyrme-Jones A;Aziz S;Sammut E;Dastidar A
通讯作者：
Dastidar A
影响因子：
8.3
作者：
Banerjee A;Chen S;Pasea L;Lai AG;Katsoulis M;Denaxas S;Nafilyan V;Williams B;Wong WK;Bakhai A;Khunti K;Pillay D;Noursadeghi M;Wu H;Pareek N;Bromage D;McDonagh TA;Byrne J;Teo JTH;Shah AM;Humberstone B;Tang LV;Shah ASV;Rubboli A;Guo Y;Hu Y;Sudlow CLM;Lip GYH;Hemingway H
通讯作者：
Hemingway H
影响因子：
39.3
作者：
De Rosa, Salvatore;Spaccarotella, Carmen;Indolfi, Ciro
通讯作者：
Indolfi, Ciro
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
18.2
作者：
Bromage, Daniel I.;Cannata, Antonio;McDonagh, Theresa A.
通讯作者：
McDonagh, Theresa A.