Biodegradable luminescent porous silicon nanoparticles for in vivo applications.
Biodegradable luminescent porous silicon nanoparticles for in vivo applications.
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作者：
可以在体内循环的纳米材料在诊断和治疗疾病方面具有巨大的潜力。对于此类应用，重要的是在纳米材料发挥诊断或治疗功能后的合理时间内无害地从体内清除。尽管努力提高其靶向效率，但大量系统给药的纳米材料在找到目标之前被单核吞噬系统清除，增加了意外急性或慢性毒性的可能性。然而，很少有人努力将错误纳米颗粒的自我破坏设计成无毒的、被系统消除的产品。在这里，我们提出了可以携带药物有效载荷的发光多孔硅纳米颗粒（LPSiNPs），其固有的近红外光致发光能够监测体内的积累和降解。此外，与大多数光学活性纳米材料（碳纳米管，金纳米颗粒和量子点）相比，LPSiNPs在小鼠模型中自毁，在相对较短的时间内被完全清除，没有毒性的证据。作为初步的体内应用，我们展示了使用葡聚糖包被的LPSiNPs （D-LPSiNPs）进行肿瘤成像。这些结果证明了一种具有低毒性降解途径的新型多功能纳米结构可用于体内应用。
Nanomaterials that can circulate in the body hold great potential to diagnose and treat disease. For such applications, it is important that the nanomaterials be harmlessly eliminated from the body in a reasonable period of time after they carry out their diagnostic or therapeutic function. Despite efforts to improve their targeting efficiency, significant quantities of systemically administered nanomaterials are cleared by the mononuclear phagocytic system before finding their targets, increasing the likelihood of unintended acute or chronic toxicity. However, there has been little effort to engineer the self-destruction of errant nanoparticles into non-toxic, systemically eliminated products. Here, we present luminescent porous silicon nanoparticles (LPSiNPs) that can carry a drug payload and of which the intrinsic near-infrared photoluminescence enables monitoring of both accumulation and degradation in vivo. Furthermore, in contrast to most optically active nanomaterials (carbon nanotubes, gold nanoparticles and quantum dots), LPSiNPs self-destruct in a mouse model into renally cleared components in a relatively short period of time with no evidence of toxicity. As a preliminary in vivo application, we demonstrate tumour imaging using dextran-coated LPSiNPs (D-LPSiNPs). These results demonstrate a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications.
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影响因子：
29.4
作者：
Mangolini, Lorenzo;Kortshagen, Uwe
通讯作者：
Kortshagen, Uwe
DOI：
10.1073/pnas.0707654105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Liu, Zhuang;Davis, Corrine;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
64.8
作者：
Sengupta, S;Eavarone, D;Sasisekharan, R
通讯作者：
Sasisekharan, R
影响因子：
82.9
作者：
Lee, Jae-Hyun;Huh, Yong-Min;Cheon, Jinwoo
通讯作者：
Cheon, Jinwoo
影响因子：
29.4
作者：
Canham, LT
通讯作者：
Canham, LT