Traumatic experiences, major life stressors, and self-reporting a physician-given fibromyalgia diagnosis.
Traumatic experiences, major life stressors, and self-reporting a physician-given fibromyalgia diagnosis.
复制标题
DOI：
10.1016/j.psychres.2009.08.017
复制
发表时间：
2010-05-30
影响因子：
11.3
通讯作者：
Fraser, Gary E.
中科院分区：
文献类型：
--
作者：
Haviland, Mark G.;Morton, Kelly R.;Oda, Keiji;Fraser, Gary E.
应激在纤维肌痛的病理生理学中的作用一直是相当大的争论主题。本研究的主要目的是评估创伤和主要生活应激源之间的关系，以及在一大群老年女性和男性中诊断纤维肌痛的情况。数据来自联邦资助的生物心理社会宗教与健康研究，受试者是10988名受访者中的10424人-三分之二的女性和三分之一的男性-回答纤维肌痛的问题。平均年龄61.0±13.5岁。3.7%的样本、4.8%的女性和1.3%的男性报告了医生在受试者一生中做出的纤维肌痛诊断。在两个多变量Logistic回归模型中(所有受访者和女性，控制了年龄、性别、种族/民族和教育)，两种创伤经历类型(性和身体攻击/虐待)与纤维肌痛的诊断有关。其他两种创伤类型(危及生命和情感虐待/忽视)和主要生活压力经历则不是。在这两个模型中，赔率最高的是性侵犯/虐待，其次是身体攻击/虐待。年龄和纤维肌痛之间的关系在两种模型中都是曲线的(优势比上升到大约63岁，之后下降)。在所有受试者的模型中，女性增加了纤维肌痛诊断的几率，在两个模型中，纤维肌痛与白人(而不是非白人)和较低的教育程度有关。我们建议研究人员结合遗传学和生物标记物研究来研究压力和纤维肌痛之间的关系。
The contribution of stress to the pathophysiology of fibromyalgia has been the subject of considerable debate. The primary purpose of the present study was to evaluate the relationship between traumatic and major life stressors and a fibromyalgia diagnosis in a large group of older women and men. Data were from the federally-funded Biopsychosocial Religion and Health Study, and subjects were 10,424 of the 10,988 survey respondents—two-thirds women and one-third men—providing responses to a fibromyalgia question. Average age was 61.0 ± 13.5 years. A physician-given fibromyalgia diagnosis in a subject’s lifetime was reported by 3.7% of the sample, 4.8% of the women and 1.3% of the men. In two multivariable logistic regression models (all respondents and women only, controlling for age, sex, race/ethnicity, and education), two traumatic experience types (sexual and physical assault/abuse) were associated with a fibromyalgia diagnosis. Two other trauma types (life-threatening and emotional abuse/neglect) and major life stress experiences were not. The highest odds ratios in both models were those for sexual assault/abuse followed by physical assault/abuse. The relationship between age and fibromyalgia was curvilinear in both models (odds ratios rising until approximately age 63 and declining thereafter). In the all-subjects model, being a woman increased the odds of a fibromyalgia diagnosis, and in both models, fibromyalgia was associated with being White (versus non-White) and lower education. We recommend that researchers investigate the relationship between stress and fibromyalgia in concert with genetic and biomarker studies.
登录
查看更多内容
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
3.7
作者：
Raphael, Karen G;Chandler, Helena K;Ciccone, Donald S
通讯作者：
Ciccone, Donald S
影响因子：
3.8
作者：
Cusack, KJ;Frueh, BC;Brady, KT
通讯作者：
Brady, KT
影响因子：
27.4
作者：
Carmona, L;Ballina, J;Laffon, A
通讯作者：
Laffon, A
影响因子：
3.7
作者：
Inanici, Fatma;Yunus, Muhammad B
通讯作者：
Yunus, Muhammad B