A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer.
A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer.
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DOI：
10.1038/sj.bjc.6603029
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发表时间：
2006-03-27
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
85 名计划接受化疗的早期乳腺癌女性、43 名计划接受内分泌治疗和/或放疗的女性以及 49 名健康对照受试者在基线 (T1)、化疗后（或 6 个月）(T2) 和 18 个月 (T3) 时的神经心理学表现进行了评估。重复测量分析发现，在控制年龄和智力后，群体之间没有显着的交互作用或主效应。通过计算检查个体水平的表现，在 T2 时，20% 的化疗患者、26% 的非化疗患者和 18% 的对照组在多项任务上出现了可靠的下降（T3 时分别为 18%、14% 和 11%）。经历过治疗引起的更年期的患者更有可能在 T2 时的多项指标上表现出可靠的下降（OR=2.6，95% 置信区间 (CI) 0.823–8.266 P=0.086）。心理困扰、生活质量测量和自我报告的认知失败并不影响认知功能的客观测试，但彼此之间显着相关。结果表明，一些女性在接受标准辅助治疗后，注意力和记忆力发生了客观可测量的变化，但大多数女性要么不受影响，甚至随着时间的推移而有所改善。
The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis found no significant interactions or main effect of group after controlling for age and intelligence. Using a calculation to examine performance at an individual level, reliable decline on multiple tasks was seen in 20% of chemotherapy patients, 26% of nonchemotherapy patients and 18% of controls at T2 (18%, 14 and 11%, respectively, at T3). Patients who had experienced a treatment-induced menopause were more likely to show reliable decline on multiple measures at T2 (OR=2.6, 95% confidence interval (CI) 0.823–8.266 P=0.086). Psychological distress, quality of life measures and self-reported cognitive failures did not impact on objective tests of cognitive function, but were significantly associated with each other. The results show that a few women experienced objective measurable change in their concentration and memory following standard adjuvant therapy, but the majority were either unaffected or even improve over time.
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影响因子：
4.7
作者：
Yellen, SB;Cella, DF;Kaplan, E
通讯作者：
Kaplan, E
DOI：
10.1093/jnci/90.3.210
发表时间：
1998-02-04
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
van Dam, FSAM;Schagen, SB;Rodenhuis, S
通讯作者：
Rodenhuis, S
影响因子：
5.9
作者：
JACOBSON, NS;TRUAX, P
通讯作者：
TRUAX, P
影响因子：
6.2
作者：
Wefel, JS;Lenzi, R;Meyers, CA
通讯作者：
Meyers, CA
影响因子：
3.9
作者：
Shilling, V;Jenkins, V;Bloomfield, D
通讯作者：
Bloomfield, D