Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making.
Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making.
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作者：
产前前扣带皮层（pACC）与人类焦虑症和抑郁症有关，但这些疾病背后的回路水平机制尚不清楚。我们将其作为线索证据，在健康个体中，pACC参与了成本效益评估。我们开发了一种猕猴版本的方法回避决策任务，用于评估人类的焦虑和抑郁，并通过多电极记录和皮层微刺激，我们探测了猴子执行该任务时的pACC功能。我们发现猕猴前扣皮层具有一个对手过程式的神经元组织，代表动机上的积极和消极的主观价值。这两个神经元群在空间上重叠，但在一个pACC亚区，负编码的神经元数量更多。引人注目的是，这一区域的微刺激增加了消极的决策，而抗焦虑药物治疗阻止了这种消极的偏见。这一皮层区域可能对调节决策过程中的消极情绪效价和焦虑至关重要。
The pregenual anterior cingulate cortex (pACC) has been implicated in human anxiety disorders and depression, but the circuit-level mechanisms underlying these disorders are unclear. We took as a clue evidence that in healthy individuals, the pACC is involved in cost-benefit evaluation. We developed a macaque version of an approach-avoidance decision task used to evaluate anxiety and depression in humans and, with multi-electrode recording and cortical microstimulation, we probed pACC function as monkeys performed this task. We found that the macaque pACC has an opponent-process like organization of neurons representing motivationally positive and negative subjective value. These two neuronal populations overlapped spatially, except in one pACC subzone, where neurons with negative coding were more numerous. Strikingly, microstimulation in this subzone, but not elsewhere in the pACC, increased negative decision-making, and this negative biasing was blocked by anti-anxiety drug treatment. This cortical zone could be critical for regulating negative emotional valence and anxiety in decision-making.
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DOI：
10.1126/science.1168488
发表时间：
2009-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hayden BY;Pearson JM;Platt ML
通讯作者：
Platt ML
额叶中的神经元编码多个决策变量的值。
影响因子：
3.2
作者：
Kennerley SW;Dahmubed AF;Lara AH;Wallis JD
通讯作者：
Wallis JD
影响因子：
10.6
作者：
Kasai, Kiyoto;Yamasue, Hidenori;Pitman, Roger K.
通讯作者：
Pitman, Roger K.
影响因子：
16.2
作者：
Mayberg, HS;Lozano, AM;Kennedy, SH
通讯作者：
Kennedy, SH
影响因子：
56.9
作者：
Ito, S;Stuphorn, V;Schall, JD
通讯作者：
Schall, JD